[图书][B] Cell Targeted Ribosome Inactivating Proteins Derived from Protein Combinatorial Libraries
S Perampalam - 2008 - library-archives.canada.ca
Combinatorial protein libraries based on a protein template offer a vast potential for deriving
protein variants harboring new receptor specificity while retaining other tem-plate functions …
protein variants harboring new receptor specificity while retaining other tem-plate functions …
Ribosome-inactivating proteins: from plant defense to tumor attack
M de Virgilio, A Lombardi, R Caliandro, MS Fabbrini - Toxins, 2010 - mdpi.com
Ribosome-inactivating proteins (RIPs) are EC3. 2.32. 22 N-glycosidases that recognize a
universally conserved stem-loop structure in 23S/25S/28S rRNA, depurinating a single …
universally conserved stem-loop structure in 23S/25S/28S rRNA, depurinating a single …
[PDF][PDF] Therapeutic application of genetically engineered ribosome-inactivating toxin proteins for cancer
SU Khan - Journal ISSN, 2021 - academia.edu
Most molecular target-based therapeutic research facilities use two basic techniques:
protein-kinase inhibitors and monoclonal antibodies. However, they continue to face …
protein-kinase inhibitors and monoclonal antibodies. However, they continue to face …
Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
P Eric, E Willert, J Kim, J Higgins - 2015 - Google Patents
the present invention relates to methods of screening molecular libraries in order to identify
cytotoxic recombinant polypeptides, each polypeptide comprising a target binding region …
cytotoxic recombinant polypeptides, each polypeptide comprising a target binding region …
Methods of screening, selecting, and identifying cytotoxic recombinant polypeptides based on an interim diminution of ribotoxicity
P Eric, E Willert, J Kim, J Higgins - US Patent App. 16/540,789, 2019 - Google Patents
the present invention relates to methods of screening molecular libraries in order to identify
cytotoxic recombinant polypeptides, each polypeptide comprising a target binding region …
cytotoxic recombinant polypeptides, each polypeptide comprising a target binding region …
Construction and analysis of high-complexity ribosome display random peptide libraries
LM Yang, JL Wang, L Kang, S Gao, Y Liu, TM Hu - PLoS One, 2008 - journals.plos.org
Random peptide libraries displayed on the ribosome are becoming a new tool for the in vitro
selection of biologically relevant macromolecules, including epitopes, antagonists, enzymes …
selection of biologically relevant macromolecules, including epitopes, antagonists, enzymes …
Unnatural RNA display libraries
Combinatorial peptide and protein libraries have now been developed to accommodate
unnatural amino acids in a genetically encoded format via in vitro nonsense and sense …
unnatural amino acids in a genetically encoded format via in vitro nonsense and sense …
[PDF][PDF] Random peptide library for ligand and drug discovery
T Kubo - Toxins and drug discovery, 2017 - academia.edu
In ancient times, natural extracts that derived mainly from plants and animals were utilized
for medical or religious purposes. Even after starting the drug discovery and development in …
for medical or religious purposes. Even after starting the drug discovery and development in …
Identifying lead peptides from epitope libraries
JK Scott - Biological Approaches to Rational Drug Design, 2022 - taylorfrancis.com
This chapter describes the current synthetic and fusion protein libraries in use, to assess the
relative advantages and disadvantages of these emerging technologies, and to outline the …
relative advantages and disadvantages of these emerging technologies, and to outline the …
Enhanced cytotoxic activity of a bifunctional chimeric protein containing a type 1 ribosome-inactivating protein and a serine protease inhibitor
Both ribosome-inactivating proteins (RIPs) and plant proteinase inhibitors, belong to protein
families known to regulate cellular homeostasis and likely involved in plant defense …
families known to regulate cellular homeostasis and likely involved in plant defense …