Non–small cell lung cancer, PD-L1, and the pathologist

KM Kerr, MC Nicolson - Archives of pathology & laboratory …, 2016 - meridian.allenpress.com
Context Although most primary cancers of the lung carry a heavy mutational load and will
potentially present many “nonself” antigens to the immune system, there are a wide range of …

Comparison of 22C3 PharmDx and SP263 assays to test PD-L1 expression in NSCLC

MA Sughayer, F Alnaimy, AM Alsughayer… - Applied …, 2019 - journals.lww.com
Immunohistochemical assays for programmed cell death ligand 1 (PD-L1) expression in non–
small cell lung cancer (NSCLC) are either required or recommended to guide therapy with …

[HTML][HTML] Immunotherapy with checkpoint inhibitors in non-small cell lung cancer: insights from long-term survivors

E Nadal, B Massuti, M Dómine… - Cancer Immunology …, 2019 - Springer
Immune checkpoint inhibitors (ICIs) targeting the programmed cell death-1 (PD-1)–
programmed cell death ligand-1 (PD-L1) axis have shown promising results in non-small …

Spatial and temporal heterogeneity of PD-L1 and its impact on benefit from immune checkpoint blockade in non-small cell lung cancer (NSCLC).

L Hong, S Dibaj, MV Negrao, A Reuben, E Roarty… - 2019 - ascopubs.org
9017 Background: Temporal and spatial heterogeneity of PD-L1 has been reported.
However, its impact on clinical benefit from immune checkpoint inhibitor (ICI) has not been …

[HTML][HTML] Assessing PDL-1 and PD-1 in non–small cell lung cancer: a novel immunoscore approach

EE Paulsen, TK Kilvaer, MR Khanehkenari… - Clinical lung cancer, 2017 - Elsevier
Introduction Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1)
or its ligand, PD-L1, have gained momentum in the treatment of non–small cell lung cancer …

PD-L1 expression in circulating tumor cells as a promising prognostic biomarker in advanced non–small-cell lung cancer treated with immune checkpoint inhibitors

FG Dall'Olio, F Gelsomino, N Conci, L Marcolin… - Clinical Lung Cancer, 2021 - Elsevier
Abstract Background Circulating tumor cells (CTCs) are a promising source of biological
information in cancer. Data correlating PD-L1 expression in CTCs with patients' response to …

Biomarkers for immune checkpoint inhibitors in advanced nonsmall cell lung cancer

R Pirker - Current Opinion in Oncology, 2019 - journals.lww.com
Biomarkers for immune checkpoint inhibitors in advanced nons... : Current Opinion in
Oncology Biomarkers for immune checkpoint inhibitors in advanced nonsmall cell lung cancer …

Emerging biomarkers for immune checkpoint inhibition in lung cancer

G Cyriac, L Gandhi - Seminars in cancer biology, 2018 - Elsevier
Immune checkpoint inhibition with anti-PD-1 therapy has been notably successful in non-
small cell lung cancer (NSCLC) and changed standard practice in multiple settings …

PD-L1 assessment in cytology samples predicts treatment response to checkpoint inhibitors in NSCLC

SCM Lau, M Rabindranath, J Weiss, JJN Li, AS Fung… - Lung Cancer, 2022 - Elsevier
Background Testing for tumor programmed death ligand-1 (PD-L1) expression was initially
developed with histology specimens in non-small cell lung cancer (NSCLC). However …

Efficacy of immune checkpoint inhibitors according to PD‐L1 tumor proportion scores in non‐small cell lung cancer

S Park, YD Choi, J Kim, BG Kho, CK Park, IJ Oh… - Thoracic …, 2020 - Wiley Online Library
Background We correlated the tumor proportion score (TPS) of programmed cell death
ligand 1 (PD‐L1, SP263 or 22C3) expression with the disease control rate (DCR, partial …