Role of exosomes and exosomal microRNAs in cancer

N Dilsiz - Future science OA, 2020 - Taylor & Francis
A growing body of evidence indicates that exosomes play a critical role in the cell–cell
communication process. Exosomes are biological nanoparticles with an average diameter of …

Exosomes: small vesicles participating in intercellular communication

AK Ludwig, B Giebel - The international journal of biochemistry & cell …, 2012 - Elsevier
Exosomes are small membrane vesicles, which eukaryotic cells secrete into their
extracellular environment. They are formed as intraluminal vesicles by inward budding of the …

[HTML][HTML] Exosomes and cancer-Diagnostic and prognostic biomarkers and therapeutic vehicle

X Wang, L Tian, J Lu, IOL Ng - Oncogenesis, 2022 - nature.com
Exosomes belong to a subpopulation of extracellular vesicles secreted by the dynamic
multistep endocytosis process and carry diverse functional molecular cargoes, including …

[HTML][HTML] Challenges and opportunities in exosome research—Perspectives from biology, engineering, and cancer therapy

X Li, AL Corbett, E Taatizadeh, N Tasnim, JP Little… - APL …, 2019 - pubs.aip.org
ABSTRACT Exosomes are small ($30–140 nm) lipid bilayer-enclosed particles of
endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most …

[HTML][HTML] The exosome journey: from biogenesis to uptake and intracellular signalling

S Gurung, D Perocheau, L Touramanidou… - Cell Communication and …, 2021 - Springer
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials
testing exosomes for diagnostic and therapeutic applications are generating remarkable …

Biogenesis and secretion of exosomes

J Kowal, M Tkach, C Théry - Current opinion in cell biology, 2014 - Elsevier
Highlights•ESCRT proteins, lipids and tetraspanins can independently generate intraluminal
vesicles.•Different RAB proteins can target multivesicular compartments to the plasma …

[HTML][HTML] Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes

S Gurunathan, MH Kang, M Jeyaraj, M Qasim, JH Kim - Cells, 2019 - mdpi.com
Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids,
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …

Exosomes and cancer: From oncogenic roles to therapeutic applications

S Mohammadi, F Yousefi, Z Shabaninejad… - IUBMB …, 2020 - Wiley Online Library
Exosomes belong to extracellular vehicles that were produced and secreted from most
eukaryotic cells and are involved in cell‐to‐cell communications. They are an effective …

[HTML][HTML] Current knowledge on exosome biogenesis and release

NP Hessvik, A Llorente - Cellular and Molecular Life Sciences, 2018 - Springer
Exosomes are nanosized membrane vesicles released by fusion of an organelle of the
endocytic pathway, the multivesicular body, with the plasma membrane. This process was …

[HTML][HTML] Exosome: a new player in translational nanomedicine

H Aheget, M Tristán-Manzano, L Mazini… - Journal of Clinical …, 2020 - mdpi.com
Exosomes are extracellular vesicles released by the vast majority of cell types both in vivo
and ex vivo, upon the fusion of multivesicular bodies (MVBs) with the cellular plasma …