Evidence is accumulating to suggest that the inducible isoenzyme of cyclooxygenase (COX)-
2 is up-regulated in human cancers and epidemiological studies indicate that COX inhibitors …

Non-small cell lung cancer (NSCLC) cells are known to constitutively overexpress
cyclooxygenase (COX)-2. Tumor COX-2-dependent production of PGE2 triggers the …

Cleavage polyadenylation specificity factor (CPSF) is the core component of the 3'‑end
processing complex, which determines the site of 3'‑end cleavage interactions of specific …

Cyclooxygenase-2 (COX-2) is constitutively expressed in most human primary carcinomas
and with its synthesized product, prostaglandin E2 (PGE2), appears to play important roles …

Background Cyclooxygenase‐2‐derived prostaglandin E2 (PGE2) stimulates tumor cell
growth and progression. α7 nicotinic acetylcholine receptor (nAChR) is a major mediator of …

Cyclooxygenase-2 (COX-2) is a key enzyme in the production of prostaglandins and
thromboxanes from free arachidonic acid. Increasing evidence suggests that COX-2 plays a …

Evaluation of: Tsubochi H, Nobuyuki S, Hiyama M et al.: Combined analysis of
cyclooxygenase-2 expression with p53 and Ki-67 in nonsmall cell lung cancer. Ann. Thorac …

The GINS complex associates with cell division cycle (Cdc) protein 45 and mini‐
chromosome maintenance (Mcm) proteins 2–7 to form the Cdc45–Mcm–GINS (CMG) …

Background Tumor necrosis factor α-induced protein 1 (TNFAIP1) is frequently
downregulated in cancer cell lines and promotes cancer cell apoptosis. However, its role …

The inducible isoenzyme cyclooxygenase-2 (COX-2) is an important hub in cellular
signaling, which contributes to tumor progression by modulating and enhancing a pro …