Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC

M Romero, R Jiménez, M Sánchez… - Atherosclerosis, 2009 - Elsevier
Chronic administration of the most abundant dietary flavonoid quercetin exerts
antihypertensive effects and improves endothelial function. We have investigated the effects …

[HTML][HTML] Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta

M Sanchez, F Lodi, R Vera, IC Villar, A Cogolludo… - The Journal of …, 2007 - Elsevier
The dietary flavonoid quercetin reduces blood pressure and improves endothelial function in
several rat models of hypertension. We analyzed the effects of quercetin and its methylated …

Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels

NKH Khoo, CR White, L Pozzo-Miller, F Zhou… - Free Radical Biology …, 2010 - Elsevier
Considerable epidemiological evidence indicates that dietary consumption of moderate
levels of polyphenols decreases both the incidence of cardiovascular disease and the …

Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats

M Sánchez, M Galisteo, R Vera, IC Villar… - Journal of …, 2006 - journals.lww.com
Results In SHR, quercetin reduced the increase in blood pressure and heart rate and
enhanced the endothelium-dependent aortic vasodilation induced by acetylcholine, but had …

Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta

F Lodi, R Jimenez, L Moreno, PA Kroon, PW Needs… - Atherosclerosis, 2009 - Elsevier
Epidemiological studies have reported an inverse association between dietary flavonoid
intake and mortality for ischemic heart disease. Quercetin reduces blood pressure and …

Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase

R López-Sepúlveda, M Gómez-Guzmán… - Clinical …, 2011 - portlandpress.com
RWPs (red wine polyphenols) exert antihypertensive effects and improve endothelial
function by reducing the plasma levels of ET-1 (endothelin-1) and the subsequent vascular …

Quercetin induces rapid eNOS phosphorylation and vasodilation by an Akt-independent and PKA-dependent mechanism

PG Li, L Sun, X Han, S Ling, W Gan, JW Xu - Pharmacology, 2012 - karger.com
Consumption of the flavonoid quercetin exerts beneficial effects on many chronic diseases.
The mechanisms involved in the vasorelaxant effect of quercetin remain uncertain. In the …

Quercetin and its metabolites improve vessel function by inducing eNOS activity via phosphorylation of AMPK

Y Shen, KD Croft, JM Hodgson, R Kyle, ILE Lee… - Biochemical …, 2012 - Elsevier
Quercetin is a major flavonoid in a wide range of fruits and vegetables. Consumption of
quercetin may contribute to a reduction in risk of cardiovascular disease (CVD). Following …

Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols

F Perez-Vizcaino, J Duarte… - Free radical …, 2006 - Taylor & Francis
Endothelial dysfunction is an early pathophysiological feature and independent predictor of
poor prognosis in most forms of cardiovascular diseases. Epidemiological studies report an …

Quercetin inhibited endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice: critical roles for NADPH oxidase and heme oxygenase-1

M Luo, R Tian, N Lu - Journal of Agricultural and Food Chemistry, 2020 - ACS Publications
NADPH oxidase-dependent superoxide (O2·–) production and oxidative stress play
important roles in endothelial dysfunction and atherosclerosis. Herein, we investigated the …