A large amount of data is available on the functional impact of missense mutations in TP53
and on mutation patterns in many different cancers. New data on mutant p53 protein …

Importance Li-Fraumeni syndrome, usually characterized by germlineTP53mutations, is
associated with markedly elevated lifetime risks of multiple cancers, and has been linked to …

Background Heterozygous germline TP53 gene mutations result in Li-Fraumeni Syndrome
(LFS). Breast cancer (BC) is the most frequent tumor in young women with LFS. An important …

Fifty years after the recognition of the Li–Fraumeni syndrome (LFS), our perception of
cancers related to germline alterations of TP53 has drastically changed:(i) germline TP53 …

Abstract An Arg/Pro polymorphism in codon 72 of the TP53 gene was analyzed in blood
samples from 390 breast and 162 colorectal cancer patients previously investigated for …

The Li–Fraumeni syndrome (LFS) and its variant form (LFL) is a familial predisposition to
multiple forms of childhood, adolescent, and adult cancers associated with germ-line …

Constitutional pathogenic variants in TP53 are associated with Li-Fraumeni syndrome or the
more recently described heritable TP53-related cancer syndrome and are associated with …

Surveillance recommendations for patients with germline TP53... : Current Opinion in
Oncology Surveillance recommendations for patients with germline TP53 mutations : Current …

Mutations on the TP53 tumor suppressor gene and allele loss on chromosome 17p, where
this gene has been located, are among the most frequent alterations yet identified in human …

Germ-line p53 mutations have been identified in most families with Li-Fraumeni syndrome
(LFS). For germ-line p53 mutation carriers, there is considerable variability with respect to …