Mutations on the TP53 tumor suppressor gene and allele loss on chromosome 17p, where
this gene has been located, are among the most frequent alterations yet identified in human …

Li-Fraumeni syndrome (LFS) is a rare hereditary cancer syndrome associated with an
autosomal-dominant mutation inheritance in the TP53 tumor suppressor gene and a wide …

Germ-line p53 mutations have been identified in most families with Li-Fraumeni syndrome
(LFS). For germ-line p53 mutation carriers, there is considerable variability with respect to …

Amid the complexity of genetic alterations in human cancer, TP53 mutation appears as an
almost invariant component, representing by far the most frequent genetic alteration overall …

Lung cancer is primarily caused by tobacco smoking, but susceptibility is likely modified by
common genetic variation. In response to many forms of cellular stress, including DNA …

It is well known that early-onset breast cancer may be due to an inherited predisposition.
When evaluating women diagnosed with breast cancer under age 30, two important …

TP53 alteration is the most frequent genetic alteration found in human cancers. To date,
more than 15,000 tumors with TP53 mutations have been published, leading to the …

Simple Summary TP53 variants detected in blood represent a main genetic cause of breast
cancers occurring before 31 years of age. TP53 being included in most of the cancer gene …

Germ-line p53 mutations are associated with dominantly inherited Li-Fraumeni syndrome
(LFS), which features early-onset sarcomas of bone and soft tissues, carcinomas of the …

The absence of detectable germline TP53 mutations in a fraction of families with Li–
Fraumeni syndrome (LFS) has suggested the involvement of other genes, but this …