How perception of pain emerges from neural activity is largely unknown. Identifying a neural
'pain signature'and deriving a way to predict perceived pain from brain activity would have …

Pain is a complex, multidimensional experience that has defied our understanding for
centuries. Through the advent of noninvasive neuroimaging techniques, we have been able …

Background: Because of the subjective nature of current pain assessments, limited efficacy
of treatment options and risks associated with opioid abuse and diversion, the need for …

This review expounds on types and properties of biomarkers for chronic pain, given a
mechanistic model of processes underlying development of chronic pain. It covers advances …

The translation of brief, millisecond-long pain-eliciting stimuli to the subjective perception of
pain is associated with changes in theta, alpha, beta, and gamma oscillations over …

Valid and reliable biomarkers can play an important role in clinical trials as indicators of
biological or pathogenic processes or as a signal of treatment response. Currently, there are …

Chronic pain is an important public health problem, and there is a need to understand the
mechanisms that lead to pain chronification. From a neurobiological perspective, the …

The great advances in brain imaging techniques over the last few decades have determined
a shift in our understanding of chronic pain conditions and opened the door for new …

Although self-report pain ratings are the gold standard in clinical pain assessment, they are
inherently subjective in nature and significantly influenced by multidimensional contextual …

Biomarkers indicating characteristic alterations in the brains of pain patients would in
comparison to behavioral examinations allow for earlier diagnoses of pain disease …