Arguments made for the advantages of replacing pain ratings with brain-imaging data
include assumptions that pain ratings are less reliable and objective and that brain image …

Pain diagnosis and management would benefit from the development of objective markers
of nociception and pain. Current research addressing this issue has focused on five main …

Chronic pain is the greatest source of disability globally and claims related to chronic pain
feature in many insurance and medico-legal cases. Brain imaging (for example, functional …

Neuroimaging of pain in animals allows us to better understand mechanisms of pain
processing and modulation. In this review, we discuss recently published brain imaging …

Chronic pain is a state of physical suffering strongly associated with feelings of anxiety,
depression and despair. Disease pathophysiology, psychological state, and social milieu …

Characterizing cerebral contributions to individual variability in pain processing is crucial for
personalized pain medicine, but has yet to be done. In the present study, we address this …

Chronic pain syndromes are often refractory to treatment and cause substantial suffering
and disability. Pain severity is often measured through subjective report, while objective …

Chronic pain is characterised by an ongoing and fluctuating intensity over time. Here, we
investigated how the trajectory of the patients' endogenous pain is encoded in the brain. In …

Pain is a complex sensory and emotional experience that is heavily influenced by prior
experience and expectations of pain. Before the development of noninvasive human brain …

As we approach the new millennium, it is clear that we are on the brink of a major change in
clinical pain management. We are poised to move from a treatment paradigm that has been …