Central neuropathic pain arises from a lesion or disease of the central somatosensory
nervous system such as brain injury, spinal cord injury, stroke, multiple sclerosis or related …

Background Adequate pain assessment is critical for evaluating the efficacy of analgesic
treatment in clinical practice and during the development of new therapies. Yet the currently …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

The transition from acute to chronic musculoskeletal pain is not well understood. To
understand this transition, it is important to know how peripheral and central sensitization …

Chronic pain is a frequent component of many neurological disorders, affecting 20–40% of
patients for many primary neurological diseases. These diseases result from a wide range of …

Neuropathic pain is caused by a lesion or disease of the somatosensory system, including
peripheral fibres (Aβ, Aδ and C fibres) and central neurons, and affects 7–10% of the …

For centuries, clinicians have been taught to examine and classify patients on the basis of
topographical lesion and the underlying pathology. In most clinical specialities, such an …

The brainstem is known to be an important brain area for nociception and pain processing,
and both relaying and coordinating signaling between the cerebrum, cerebellum, and spinal …

Pain is an internal, subjective experience that cannot be measured by the use of physiologic
markers or bioassays. The assessment of pain, therefore, relies largely (often exclusively) on …

The perception of pain is characterized by its tremendous intra-and interindividual variability.
Different individuals perceive the very same painful event largely differently. Here, we aimed …