Atherosclerosis is a chronic disease characterized by the deposition of excessive
cholesterol in the arterial intima. Macrophage foam cells play a critical role in the occurrence …

Introduction 3. Nature of lipid in foam cells 4. Sources of cholesterol that accumulates in
foam cells 5. Significance of foam cell formation 5.1. Trapping lipid in lesions versus …

During atherosclerosis, the gradual accumulation of lipids into the subendothelial space of
damaged arteries results in several lipid modification processes followed by macrophage …

Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is
maintained by specialized cells, such as macrophages. Macrophages express a variety of …

Cardiovascular disease is the biggest killer globally and the principal contributing factor to
the pathology is atherosclerosis; a chronic, inflammatory disorder characterized by lipid and …

Foam cell formation due to excessive accumulation of cholesterol by macrophages is a
pathological hallmark of atherosclerosis. Macrophages cannot limit the uptake of cholesterol …

Smooth muscle cells (SMCs) are the main cell type in intimal thickenings and some stages
of human atherosclerosis. Like monocyte-derived macrophages, SMCs accumulate excess …

Atherosclerosis is a chronic immune-inflammatory disease in which the interactions of
monocytes with activated endothelium are crucial events leading to atherosclerotic alteration …

Atherosclerosis is associated with acute cardiovascular conditions, such as ischemic heart
disease, myocardial infarction, and stroke, and is the leading cause of morbidity and …

So Much Cholesterol: the unrecognized importance of smooth m... : Current Opinion in
Lipidology So Much Cholesterol: the unrecognized importance of smooth muscle cells in …