Mast cells are present in atherosclerotic lesions throughout their progression. The process of
atherogenesis itself is characterized by infiltration and retention of cholesterol-containing …

HDLs protect against the development of atherosclerosis, but the underlying mechanisms
are poorly understood. HDL and its apolipoproteins can promote cholesterol efflux from …

Atherosclerosis, a chronic inflammatory disease associated with high morbidity and
mortality, is characterized by the accumulation of foam cells in the arterial wall. It has long …

In atherosclerosis, accumulation of cholesterol in macrophages may partially depend on its
defective removal by high-density lipoproteins (HDL). We studied the proteolytic effect of …

A major characteristic of advanced atherosclerotic lesions is the necrotic, or lipid, core,
which likely plays an important role in the clinical progression of these lesions. Recent data …

Pure macrophage-derived foam cells (MFC) were isolated from the aortas of rabbits made
atherosclerotic by balloon deendothelialization followed by diet-induced …

Atherosclerosis is a disease of blood vessel walls that is thought to be initiated as a reaction
of insults to the endothelium. The complex sequence of cellular events that begins with focal …

Because of a close association between platelets and macrophages in early fatty streak
lesions, the hypothesis was tested that platelets contribute to lesion progression by directly …

Atherosclerosis is a chronic, inflammatory disorder characterized by the deposition of excess
lipids in the arterial intima. The formation of macrophage-derived foam cells in a plaque is a …

Accumulation of monocytes and the entrapment of oxidized-low-density lipoprotein (ox-LDL)
in monocytes are important in the differentiation into “foam” macrophages and the …