Histone deacetylase (HDAC) inhibitors have been shown to induce cell cycle arrest and
apoptosis in cancer cells. However, the mechanisms of HDAC inhibitor induced apoptosis …

Inhibitors of histone deacetylases (HDACIs) are a new generation of anticancer agents that
selectively kill tumor cells. However, the molecular basis for their tumor selectivity is not well …

Histone deacetylase (HDAC) inhibitors modify transcription of selected genes and
eventually induce apoptosis. However, molecular mechanisms for their proapoptotic activity …

The transcription factor forkhead box O 3A (FOXO3A) is a tumor suppressor that promotes
cell cycle arrest and apoptosis. Piperlongumine (PL), a plant alkaloid, is known to selectively …

Histone deacetylase inhibitors (HDACi) can elicit a range of biological responses that
impede the growth and/or survival of tumor cells. Depending on the physiological context …

Paclitaxel is used to treat breast cancers, but the mechanisms by which it induces apoptosis
are poorly understood. Consequently, we have studied the role of the FoxO transcription …

Enhancer of zeste homolog 2 (EZH2), a subunit of polycomb repressive complex 2, is a
histone methyl‑transferase and is considered to work cooperatively with histone …

Histone acetylation marks have an important role in controlling gene expression and are
removed by histone deacetylases (HDACs). These marks are read by bromodomain and …

Histone deacetylase (HDAC) inhibitors augment ionizing radiation (IR)-induced apoptosis in
several cancer cells by undefined mechanism (s). We recently found that the HDAC …

BH3 mimetics are emerging novel anticancer therapeutics that potently and specifically
inhibit antiapoptotic BCL-2 proteins and thereby induce cell death in many cancer entities …