Background: It is well recognized that different patients respond in different ways to
medications. The inter-individual variations are greater than the intera-individual variations …

The prevalent CYP3A5* 3 and the functional multi-drug resistance gene (MDR1) C3435T
show marked interethnic variation among Orientals, Caucasians and Africans. This study …

Polymorphisms in cytochrome P450 CYP3A4 and multidrug resistance (MDR) 1 genes
coding for the important drugmetabolising CYP3A4 and the ATP-binding cassette (ABC) …

Summary P-glycoprotein (P-gp) is an ATP-dependent efflux pump which has great
importance in absorption and elimination of several important drugs. The MDR1 (Multiple …

A recent study with 69 Japanese liver transplants treated with tacrolimus found that the
MDR1 3435 C> T polymorphism, but not the MDR1 2677 G> T polymorphism, was …

The goal of this study was to detect genotypic differences between Spaniards and other
related populations regarding CYP3A4* 1B, CYP3A5* 3, and ABCB1 (MDR1) C3435T …

Background and objective: The drug transporter MDR1 and the drug metabolizing enzyme
CYP3A are the two major biological factors determining the pharmacokinetics of many …

Aims To investigate the frequency of the single nucleotide polymorphism C3435T in exon 26
of the MDR1 gene in Asians and to determine the functional significance of this SNP with the …

OBJECTIVES: To investigate the genetic variability of multiple drug resistant 1 (MDR1) gene
C3435T polymorphism in four Southern Chinese populations. METHODS: Using …

CYP3A4, CYP3A5 and MDRâ•’1 Variant Alleles in The Dutch Caucasian Population Page 1
CLINICAL PHARMACOLOGY & TH ERAPEUTICS P42 American Society Cbr Clinical …