Background: Studies have shown repeatedly that ethanol pharmacokinetics are not linear,
yet most researchers still determine ethanol elimination by linear, zero‐order kinetics. The …

This study investigated the influence of menstrual cycle and female sex steroid levels on
ethanol pharmacokinetics. In a within‐subjects design, 24 female volunteers each …

A physiological pharmacokinetic model of ethanol metabolism was used to simulate ethanol
metabolism in standard, fasted, human males of the white American, white European, black …

The pharmacokinetics of ethanol after typical doses are described by a 1-compartment
model with concentration-dependent elimination. The volume of distribution estimated from …

THE ABSORPTION, DISTRIBUTION, and elimination of ethanol in humans were studied by
Erik MP Widmark (1889–1945) during the first decades of the 20th century (Andreasson and …

The pharmacokinetics of ethanol in man are reviewed from a historical perspective from the
earliest attempts at kinetic analysis of urinary data in 1899 to the present nonlinear analysis …

The relationship between blood ethanol concentration and hepatic ethanol metabolism
commonly is calculated using the Michaelis‐Menten equation and a one‐compartment …

10 A. Dettling, S. Witte, G. Skopp, M. Graw, H. Th. Haffner, A regression model applied to
gender-specific ethanol elimination rates from blood and breath measurements in non …

Forty-eight healthy men each drank a dose of ethanol, 0.68 g/kg of body weight, as neat
whisky at about 09.00, after fasting overnight. The drink was finished within 20 min and the …

Differences in ethanol pharmacokinetics within the menstrual cycle have previously been
reported and attributed to variations in body composition, hormonal influences and gastric …