Autophagy, hallmarked by the formation of double-membrane bound organelles known as
autophagosomes, is a lysosome-dependent pathway for protein degradation. The role of …

Autophagy is an evolutionarily conserved intracellular catabolic process that is used by all
cells to degrade dysfunctional or unnecessary cytoplasmic components through delivery to …

Autophagy is a process in which subcellular membranes undergo dynamic morphological
changes that lead to the degradation of cellular proteins and cytoplasmic organelles. This …

Basal autophagy plays a critical role in maintaining cellular homeostasis and genomic
integrity by degrading aged or malfunctioning organelles and damaged or misfolded …

Autophagy constitutes one of the major responses to stress in eukaryotic cells, and is
regulated by a complex network of signaling cascades. Not surprisingly, autophagy is …

Autophagy is a catabolic program that is responsible for the degradation of dysfunctional or
unnecessary proteins and organelles to maintain cellular homeostasis. Mechanistically, it …

Non-apoptotic forms of programmed cell death are targets for novel approaches in
anticancer therapy. Indeed, cancer cells often present with mutations in the apoptotic …

Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

Autophagy is a lysosomal degradation process crucial for adaptation to stress and cellular
homeostasis. In cancer, autophagy has been demonstrated to serve multifaceted roles in …

Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells,
such a homeostatic activity constitutes a robust barrier against malignant transformation …