The zinc finger protein tristetraprolin (TTP) promotes translation repression and degradation
of mRNAs containing AU-rich elements (AREs). Although much attention has been directed …

Tristetraprolin (TTP) regulates the expression of AU-rich element-containing mRNAs through
promoting the degradation and repressing the translation of target mRNA. While the …

Abstract AU-rich elements (AREs), residing in the 3′ untranslated region (UTR) of many
labile mRNAs, are important cis-acting elements that modulate the stability of these mRNAs …

AU‐rich elements (AREs) in the 3′ untranslated region (UTR) of numerous mammalian
transcripts function as instability elements that promote rapid mRNA degradation …

Members of the tristetraprolin (TTP/TIS11) family are important RNA-binding proteins initially
characterized as mediators of mRNA degradation. They act via their interaction with AU-rich …

Tristetraprolin (TTP) binds AU-rich elements (AREs) encoded within selected labile mRNAs
and targets these transcripts for rapid cytoplasmic decay. RNA binding by TTP is mediated …

Tristetraprolin (TTP) is the prototype of a family of CCCH tandem zinc finger proteins that can
bind to AU-rich elements in mRNAs and promote their decay. TTP binds to mRNA through its …

Tristetraprolin (TTP), the best known member of a class of tandem (R/K) YKTELCX 8 CX 5
CX 3 H zinc finger proteins, can destabilize target mRNAs by first binding to AU-rich …

Changes in mRNA stability and translation are critical control points in the regulation of gene
expression, particularly genes encoding growth factors, inflammatory mediators, and proto …

Tristetraprolin (TTP) directs its target AU-rich element (ARE)-containing mRNAs for
degradation by promoting removal of the poly (A) tail. The p38 MAPK pathway regulates …