Antimyostatin treatment in health and disease: The story of great expectations and limited success
TL Nielsen, J Vissing, TO Krag - Cells, 2021 - mdpi.com
In the past 20 years, myostatin, a negative regulator of muscle mass, has attracted attention
as a potential therapeutic target in muscular dystrophies and other conditions. Preclinical …
as a potential therapeutic target in muscular dystrophies and other conditions. Preclinical …
[PDF][PDF] Myostatin: biology and clinical relevance
G Carnac, S Ricaud, B Vernus… - Mini reviews in medicinal …, 2006 - researchgate.net
Myostatin is a negative regulator of muscle mass. Important advances in our understanding
of the complex biology of this factor have revealed the therapeutic potential of antagonizing …
of the complex biology of this factor have revealed the therapeutic potential of antagonizing …
Past, present, and future perspective of targeting myostatin and related signaling pathways to counteract muscle atrophy
WMH Hoogaars, RT Jaspers - Muscle Atrophy, 2018 - Springer
Myostatin was identified more than 20 years ago as a negative regulator of muscle mass in
mice and cattle. Since then, a wealth of studies have uncovered the potential involvement of …
mice and cattle. Since then, a wealth of studies have uncovered the potential involvement of …
Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases
JF Tobin, AJ Celeste - Current opinion in pharmacology, 2005 - Elsevier
Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining
both muscle fiber number and size. The myostatin pathway is conserved and regulates …
both muscle fiber number and size. The myostatin pathway is conserved and regulates …
Myostatin in the pathophysiology of skeletal muscle
A Bonnieu, G Carnac, B Vernus - Current genomics, 2007 - ingentaconnect.com
Myostatin is an endogenous, negative regulator of muscle growth determining both muscle
fiber number and size. The myostatin pathway is conserved across diverse species ranging …
fiber number and size. The myostatin pathway is conserved across diverse species ranging …
Myostatin: Basic biology to clinical application
P Esposito, D Picciotto, Y Battaglia, F Costigliolo… - Advances in clinical …, 2022 - Elsevier
Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …
by animal and human skeletal muscle cells where it limits muscle growth and promotes …
The function of Myostatin and strategies of Myostatin blockade—new hope for therapies aimed at promoting growth of skeletal muscle
K Patel, H Amthor - Neuromuscular Disorders, 2005 - Elsevier
Genetic deletion of Myostatin, a member of the Transforming Growth Factor-beta family of
signalling molecules, resulted in excessive growth of skeletal muscle. It demonstrated the …
signalling molecules, resulted in excessive growth of skeletal muscle. It demonstrated the …
Myostatin: more than just a regulator of muscle mass
The presence of sufficient skeletal muscle mass is of paramount importance for body
function and the myostatin cascade is known to inhibit muscle growth in mammals. In …
function and the myostatin cascade is known to inhibit muscle growth in mammals. In …
[HTML][HTML] The elusive promise of myostatin inhibition for muscular dystrophy
KR Wagner - Current opinion in neurology, 2020 - journals.lww.com
The elusive promise of myostatin inhibition for muscular dys... : Current Opinion in Neurology
The elusive promise of myostatin inhibition for muscular dystrophy : Current Opinion in …
The elusive promise of myostatin inhibition for muscular dystrophy : Current Opinion in …
Myostatin: expanding horizons
M Sharma, C McFarlane, R Kambadur, H Kukreti… - IUBMB …, 2015 - Wiley Online Library
Myostatin is a secreted growth and differentiation factor that belongs to the TGF‐β
superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and …
superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and …