The progressive loss of skeletal muscle mass, strength and/or function with advancing age,
termed sarcopenia, poses a major threat to independence and quality of life. Therefore …

Current research findings in humans and other mammalian and non-mammalian species
support the potent regulatory role of myostatin in the morphology and function of muscle as …

Myostatin (Mstn) is a secreted growth factor expressed in skeletal muscle and adipose tissue
that negatively regulates skeletal muscle mass. Mstn−/− mice have a dramatic increase in …

Background Myostatin inhibition is a promising therapeutic strategy to maintain muscle mass
in a variety of disorders, including the muscular dystrophies, cachexia, and sarcopenia …

Myostatin (MSTN) is a transforming growth factor-β family member that plays a critical role in
regulating skeletal muscle mass. Genetic studies in multiple species have demonstrated that …

Myostatin, a member of the transforming growth factor-β superfamily, is a potent negative
regulator of skeletal muscle growth and is conserved in many species, from rodents to …

Myotubular myopathy, also called X-linked centronuclear myopathy (XL-CNM), is a severe
congenital disease targeted for therapeutic trials. To date, biomarkers to monitor disease …

The obesity epidemic is an overwhelming global health concern. Interventions to improve
body weight and composition aim to restore balance between nutrient intake and energy …

Myostatin, a member of the transforming growth factor-β superfamily, is an attractive target
for muscle disease therapy because of its role as a negative regulator of muscle growth and …

Myostatin (MSTN) is a well-reported negative regulator of muscle growth and a member of
the transforming growth factor (TGF) family. MSTN has important functions in skeletal muscle …