Mutations in the myostatin gene are associated with hypermuscularity, suggesting that
myostatin inhibits skeletal muscle growth. We postulated that increased tissue-specific …

Both acquired and inherited disorders of muscle are common; thus, greater understanding of
muscle growth and maintenance is important for future therapies. Myostatin down-regulates …

Myostatin, a negative regulator of muscle growth, is considered a potential therapeutic agent
for individuals suffering from various muscle wasting and strength declining diseases …

Myostatin is an extracellular cytokine mostly expressed in skeletal muscles and known to
play a crucial role in the negative regulation of muscle mass. Upon the binding to activin …

Myostatin, which was cloned in 1997, is a potent inhibitor of skeletal muscle growth and
member of the tumour growth factor-β family. Disruption of the myostatin gene in mice …

Myostatin is a negative regulator of muscle growth. Loss of myostatin has been shown to
cause increase in skeletal muscle size and improve skeletal muscle function and fibrosis in …

As myostatin is a potent inducer of muscle wasting, antagonists to myostatin have been
speculated to have great therapeutic value in alleviating muscle wasting. Indeed, myostatin …

Myostatin, a member of the transforming growth factor-β (TGF-β) superfamily, is a critical
autocrine/paracrine inhibitor of skeletal muscle growth. Since the first observed double …

Since the discovery of myostatin (MSTN; also known as GDF-8) as a critical regulator of
skeletal muscle mass in 1997, there has been an extensive effort directed at understanding …

Myostatin (MSTN), a member of the transforming growth factor-β superfamily, can negatively
regulate the growth and development of skeletal muscle by autocrine or paracrine signaling …