Acute Promyelocytic Leukaemia (APL) is associated with reciprocal and balanced
translocations that always involve the Retinoic Acid Receptor o (RARo) gene (RARA) on …

The promyelocytic leukemia (PML)‑retinoic acid receptor α (RARA) fusion is hypothesized to
serve a vital role in the pathogenesis of acute promyelocytic leukemia (APL), which results …

Acute promyelocytic leukaemia (APL) is characterized by t (15; 17)(q22; q21) which results
in the formation of two chimaeric genes, PML/RARα and RARα/PML, thought to play a role in …

Acute promyelocytic leukemia (APL) is characterized by a reciprocal translocation, t (15;
17)(q22; q12), resulting in fusion of the genes promyelocytic leukemia (PML) and retinoic …

The diagnostic hallmark of acute promyelocytic leukemia (APL) is the reciprocal
translocation t (15; 17), resulting in the characteristic PML-RARA fusion; however, patients …

Acute promyelocytic leukemia (APL) is characterized by the t (15; 17) cytogenetic
abnormality leading to the expression of two fusion genes, PML/RARA and RARA/PML, and …

Acute promyelocytic leukemia (APL) is typified by t (15; 17)(q22; q21), generating the
promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid α‑receptor (RARA) gene …

Materials and methods: We investigated 1714 newly diagnosed AML. In 92 cases an AML
M3 (n= 67) or M3v (n= 25) was diagnosed using cytomorphology. In all these cases …

Figure 1. Bone marrow, MGG staining (x1000). peutic protocol which presently includes the
use of transretinoic acid (T-RA), a differentiating agent that induces a complete remission in …

In most cases of acute promyelocytic leukemia (APL), a fusion of the promyelocytic leukemia
(PML) and the retinoic acid receptor-α (RARα) genes occurs, resulting in the expression of a …