Dynamic regulation of NK cell responsiveness

N Kadri, AK Wagner, S Ganesan, K Kärre… - Natural Killer …, 2016 - Springer
Natural killer (NK) cells deliver cytotoxic granules and immunomodulatory cytokines in
response to transformed and virally infected cells. NK cell functions are under the control of …

Inhibitory receptor-mediated regulation of natural killer cells

E Alari-Pahissa, C Grandclement… - Critical Reviews™ in …, 2014 - dl.begellhouse.com
Natural killer (NK) cells are capable of directly recognizing pathogens, pathogen-infected
cells, and transformed cells. NK cells recognize target cells using approximately 100 germ …

Line of attack: NK cell specificity and integration of signals

YT Bryceson, EO Long - Current opinion in immunology, 2008 - Elsevier
Natural killer (NK) cells possess potent cytolytic activity and secrete immune modulating
cytokines. The large repertoire of NK cell receptors provides versatility for the identification of …

Signal transduction during activation and inhibition of natural killer cells

C Watzl, EO Long - Current protocols in immunology, 2010 - Wiley Online Library
Natural killer (NK) cells are important for early immune responses to viral infections and
cancer. Upon activation, NK cells secrete cytokines and chemokines, and kill sensitive target …

Controlling natural killer cell responses: integration of signals for activation and inhibition

EO Long, H Sik Kim, D Liu, ME Peterson… - Annual review of …, 2013 - annualreviews.org
Understanding how signals are integrated to control natural killer (NK) cell responsiveness
in the absence of antigen-specific receptors has been a challenge, but recent work has …

Regulation of natural killer cell activity

SE Kirwan, DN Burshtyn - Current opinion in immunology, 2007 - Elsevier
Information regarding the role of natural killer (NK) cells in the response to viruses,
intracellular bacteria and parasites continues to emerge. NK cells can directly lyse infected …

Signaling for synergistic activation of natural killer cells

HJ Kwon, HS Kim - Immune network, 2012 - synapse.koreamed.org
Natural killer (NK) cells play a pivotal role in early surveillance against virus infection and
cellular transformation, and are also implicated in the control of inflammatory response …

Epigenetic regulation of NK cell differentiation and effector functions

F Cichocki, JS Miller, SK Anderson… - Frontiers in …, 2013 - frontiersin.org
Upon maturation, natural killer (NK) cells acquire effector functions and regulatory receptors.
New insights suggest a considerable functional heterogeneity and dynamic regulation of …

Tuning the threshold of natural killer cell responses

E Narni-Mancinelli, S Ugolini, E Vivier - Current opinion in immunology, 2013 - Elsevier
Natural killer cells are lymphocytes of the innate immune system that can kill an array of
tumor and infected cells and secrete cytokines that participate in the shaping of the adaptive …

Natural killer cell cytotoxicity and its regulation by inhibitory receptors

S Kumar - Immunology, 2018 - Wiley Online Library
Natural killer (NK) cells express an array of germ‐line encoded receptors that are capable of
triggering cytotoxicity. NK cells tend to express many members of a given family of signalling …