SARS-CoV-2 variants of concern (VOCs) have emerged worldwide, with implications on the
spread of the pandemic. Characterizing the cross-reactivity of antibodies against these …

Background Antibodies raised against human seasonal coronaviruses (sCoVs), which are
responsible for the common cold, are known to cross-react with SARS-CoV-2 antigens. This …

Immunity to previously encountered viruses can alter response to unrelated pathogens. We
reasoned that similar mechanism may also involve SARS-CoV-2 and thereby affect the …

Both the SARS-CoV-2 pandemic and emergence of variants of concern have highlighted the
need for functional antibody assays to monitor the humoral response over time. Antibodies …

Emerging SARS-CoV-2 variants of concern (VOCs) pose a threat to human immunity
induced by natural infection and vaccination. We assessed the recognition of three VOCs (B …

Background Measuring anti-viral antibody affinity in blood plasma or serum is a rational
quantitative approach to assess humoral immune response and acquired protection. Three …

SARS-CoV-2-specific antibodies, particularly those preventing viral spike receptor binding
domain (RBD) interaction with host angiotensin-converting enzyme 2 (ACE2) receptor, can …

Current SARS-CoV-2 vaccines are losing efficacy against emerging variants and may not
protect against future novel coronavirus outbreaks, emphasizing the need for more broadly …

ABSTRACT SARS-CoV-2 anti-spike antibody concentrations and angiotensin converting
enzyme-2 (ACE-2) inhibition have been used as surrogates to live viral neutralizing antibody …

Between June and November 2020, we assessed plasma antibodies against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid protein in 4996 …