Background Defective tumor suppressor genes (TSGs) and hyperactive oncogenes (OCGs)
heavily contribute to cell proliferation and apoptosis during cancer development through …

Background Cancer is a complex disease. So far, many genes have been reported to
involve in the development of cancer. Rather than the traditional approach to studying …

The role of genetic components in cancer development is an area of interest for cancer
biologists in general. Intriguingly, some genes have both oncogenic and tumor-suppressor …

Protein–protein interaction (PPI) network analysis has been widely applied in the
investigation of the mechanisms of diseases, especially cancer. Recent studies revealed …

Cancer is the leading cause of death worldwide and is generally caused by mutations in
multiple proteins or the dysregulation of pathways. Understanding the causes and the …

Data-driven discovery of cancer driver genes, including tumor suppressor genes (TSGs) and
oncogenes (OGs), is imperative for cancer prevention, diagnosis, and treatment. Although …

Background Disease genes cause or contribute genetically to the development of the most
complex diseases. Drugs are the major approaches to treat the complex disease through …

Protein-protein interaction networks provide a global picture of cellular function and
biological processes. Proteins interact largely through specific domains which constitute the …

Mutations or overexpression of signalling genes can result in cancer development and
metastasis. In this study, we manually assembled a human cellular signalling network and …

Background In terms of genomics, bioinformatics conceptualizes biological processes and
utilizes computer science to generate knowledge from biological data. Bioinformatics is …