New concepts in the pathogenesis, diagnosis and treatment of bacteremia and sepsis
R Huttunen, J Aittoniemi - Journal of Infection, 2011 - Elsevier
Bacteremia and sepsis are major health concerns. Despite intensive research, there are
only a limited number of successful treatment options, and it is difficult to see the forest for …
only a limited number of successful treatment options, and it is difficult to see the forest for …
[HTML][HTML] Sepsis and infection: two words that should not be confused
JL Vincent - Frontiers in Medicine, 2023 - frontiersin.org
The underlying cause of sepsis is a dysregulated host response to infection, leading to
multiple organ failure. Identifying sepsis is crucial because of the associated …
multiple organ failure. Identifying sepsis is crucial because of the associated …
Signaling pathways and intervention therapies in sepsis
Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …
systemic inflammatory and immune response to infection. Over decades, advanced …
Emerging therapeutic targets for sepsis
EW Tindal, BE Armstead, SF Monaghan… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: Sepsis is characterized by a dysregulated host response to infection. Sepsis-
associated morbidity/mortality demands concerted research efforts toward therapeutic …
associated morbidity/mortality demands concerted research efforts toward therapeutic …
[HTML][HTML] Infection, sepsis and the inflammatory response: mechanisms and therapy
DO Lonsdale, RV Shah, J Lipman - Frontiers in Medicine, 2020 - frontiersin.org
Sepsis secondary to bacterial infection remains a significant cause of morbidity and mortality
globally. Recent decades have seen the evolution of international collaborations to improve …
globally. Recent decades have seen the evolution of international collaborations to improve …
Pathophysiology of septic shock: From bench to bedside
KW McConnell, CM Coopersmith - La Presse Médicale, 2016 - Elsevier
Our understanding of sepsis and its resultant outcomes remains a paradox. On the one
hand, we know more about the pathophysiology of sepsis than ever before. However, this …
hand, we know more about the pathophysiology of sepsis than ever before. However, this …
[HTML][HTML] Sepsis and nosocomial infection: patient characteristics, mechanisms, and modulation
SJ Denstaedt, BH Singer, TJ Standiford - Frontiers in Immunology, 2018 - frontiersin.org
Sepsis is a leading cause of death worldwide. After initial trials modulating the
hyperinflammatory phase of sepsis failed, generations of researchers have focused on …
hyperinflammatory phase of sepsis failed, generations of researchers have focused on …
Novel evidence on sepsis-inducing pathogens: from laboratory to bedside
S Gatica, B Fuentes, E Rivera-Asín… - Frontiers in …, 2023 - frontiersin.org
Sepsis is a life-threatening condition and a significant cause of preventable morbidity and
mortality globally. Among the leading causative agents of sepsis are bacterial pathogens …
mortality globally. Among the leading causative agents of sepsis are bacterial pathogens …
[HTML][HTML] Immunopathophysiology of human sepsis
WJ Wiersinga, T van der Poll - EBioMedicine, 2022 - thelancet.com
Sepsis is an ill-defined syndrome yet is a leading cause of morbidity and mortality
worldwide. The most recent consensus defines sepsis as life-threatening organ dysfunction …
worldwide. The most recent consensus defines sepsis as life-threatening organ dysfunction …
The immunopathology of sepsis and potential therapeutic targets
T van der Poll, FL van de Veerdonk… - Nature Reviews …, 2017 - nature.com
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …
host response to infection. In sepsis, the immune response that is initiated by an invading …