New concepts in the pathogenesis, diagnosis and treatment of bacteremia and sepsis

R Huttunen, J Aittoniemi - Journal of Infection, 2011 - Elsevier
Bacteremia and sepsis are major health concerns. Despite intensive research, there are
only a limited number of successful treatment options, and it is difficult to see the forest for …

[HTML][HTML] Sepsis and infection: two words that should not be confused

JL Vincent - Frontiers in Medicine, 2023 - frontiersin.org
The underlying cause of sepsis is a dysregulated host response to infection, leading to
multiple organ failure. Identifying sepsis is crucial because of the associated …

Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Emerging therapeutic targets for sepsis

EW Tindal, BE Armstead, SF Monaghan… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: Sepsis is characterized by a dysregulated host response to infection. Sepsis-
associated morbidity/mortality demands concerted research efforts toward therapeutic …

[HTML][HTML] Infection, sepsis and the inflammatory response: mechanisms and therapy

DO Lonsdale, RV Shah, J Lipman - Frontiers in Medicine, 2020 - frontiersin.org
Sepsis secondary to bacterial infection remains a significant cause of morbidity and mortality
globally. Recent decades have seen the evolution of international collaborations to improve …

Pathophysiology of septic shock: From bench to bedside

KW McConnell, CM Coopersmith - La Presse Médicale, 2016 - Elsevier
Our understanding of sepsis and its resultant outcomes remains a paradox. On the one
hand, we know more about the pathophysiology of sepsis than ever before. However, this …

[HTML][HTML] Sepsis and nosocomial infection: patient characteristics, mechanisms, and modulation

SJ Denstaedt, BH Singer, TJ Standiford - Frontiers in Immunology, 2018 - frontiersin.org
Sepsis is a leading cause of death worldwide. After initial trials modulating the
hyperinflammatory phase of sepsis failed, generations of researchers have focused on …

Novel evidence on sepsis-inducing pathogens: from laboratory to bedside

S Gatica, B Fuentes, E Rivera-Asín… - Frontiers in …, 2023 - frontiersin.org
Sepsis is a life-threatening condition and a significant cause of preventable morbidity and
mortality globally. Among the leading causative agents of sepsis are bacterial pathogens …

[HTML][HTML] Immunopathophysiology of human sepsis

WJ Wiersinga, T van der Poll - EBioMedicine, 2022 - thelancet.com
Sepsis is an ill-defined syndrome yet is a leading cause of morbidity and mortality
worldwide. The most recent consensus defines sepsis as life-threatening organ dysfunction …

The immunopathology of sepsis and potential therapeutic targets

T van der Poll, FL van de Veerdonk… - Nature Reviews …, 2017 - nature.com
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …