Systemic immune dysregulation is generally acknowledged to be the fundamental molecular
mechanism that underlies the pathophysiology of severe sepsis and septic shock. In the …

Sepsis—which is a severe life-threatening infection with organ dysfunction—initiates a
complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be …

Sepsis is defined as “a life‐threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection.” At present, sepsis continues to …

Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the
disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving …

Multiple clinical trials of adjunctive therapy for sepsis and septic shock have been conducted
to neutralize bacterial components or to modulate host inflammatory responses to infection …

Sepsis remains a major cause of morbidity and mortality worldwide, with increased burden
in low-and middle-resource settings. The role of the inflammatory response in the …

While the term “sepsis” has been used for centuries to describe critical illness resulting from
infection, a specific definition and conceptual basis for its genesis are still debated (1–3) …

Sepsis syndromes have been recognized since antiquity yet still pose significant challenges
to modern medicine. One of the biggest challenges lies in the heterogeneity of triggers and …

Objective To review the basic differences between Gram-positive and Gram-negative sepsis
and to assess the effect of these differences on current and future therapeutic strategies for …

Sepsis, severe sepsis, and septic shock represent increasingly severe systemic
inflammatory responses to infection. Sepsis is common in the aging population, and it …