Recent investigations have clarified some of the molecular mechanisms underlying the t (15;
17) translocation specific for acute promyelocytic leukaemia (APL). Together with providing …

Acute promyelocytic leukemia (APL) is typified by the reciprocal translocation, t (15; 17)(q22;
q21), leading to the formation of PML-RARα and RARα-PML fusion genes. We have …

It is important to detect PML/RARa rearrangement in patient with morphologic acute
promyelocytic leukemia (APL). Rare cases of APL lacking the classic t (15; 17) on routine …

The molecular mechanisms underlying the t (15; 17) cytogenetic translocation of acute
promyelocytic leukaemia (APL) have been recently elucidated. Together with new insights …

The chimeric gene product PML-RAR α, the result of a reciprocal t (15; 17) translocation,
plays an important role in the pathogenesis of acute promyelocytic leukemia (APL). In the …

In more than 90% of acute promyelocytic leukemia (APL) cases a reciprocal translocation t
(15; 17)(q22; q12) can be observed. The RARα gene on 17q12 is known to have other …

Acute promyelocytic leukemias (APLs) are characterized by a translocation that involves
chromosomes 15 and 17. The translocation breakpoints have recently been identified and …

Acute promyelocytic leukaemia (APL) is characterized by t (15; 17)(q22; q21) which results
in the formation of two chimaeric genes, PML/RARα and RARα/PML, thought to play a role in …

The reciprocal translocation (15; 17) is specifically associated with acute promyelocytic
leukemia [APL; M3 subtype according to French-American-British (FAB) classification]. A few …

We have used genomic probes which specifically recognize DNA rearrangements of the
RAR‐α locus on chromosome 17q21 in patients with acute promyelocytic leukaemia (APL) …