Axotomized neurons within the damaged CNS are thought to be prevented from functional
regeneration by inhibitory molecules such as chondroitin sulfate proteoglycans (CSPGs) …

Severed axons in adult mammals do not regenerate appreciably after central nervous
system (CNS) injury due to developmentally determined reductions in neuron-intrinsic …

Spinal cord injury (SCI) causes permanent debilitation due to the inability of axons to grow
through established scars. Both the sugar chains and core proteins of chondroitin sulfate …

Astrogliosis is a defense response of the CNS to minimize primary damage and to repair
injured tissues, but it ultimately generates harmful effects by upregulating inhibitory …

Chondroitin sulfate proteoglycans (CSPGs) are the most abundant components of glial scar
formed after severe traumatic brain injury as well as spinal cord injury and play a crucial …

Chondroitin sulfate proteoglycans (CSPGs) are a major component of the glial scar that
contributes to the limited regeneration of the CNS after axonal injury. However, the …

Acute trauma to the central nervous system (CNS) can result in permanent damage and loss
of function related to the poor regeneration of injured axons. Injured axons encounter …

CNS lesions induce production of ECM molecules that inhibit axon regeneration. One major
inhibitory family is the chondroitin sulfate proteoglycans (CSPGs). Reduction of their …

Following CNS injury in the adult mammal, axon regeneration fails in scar regions
containing a number of different chondroitin sulfate-bearing proteoglycans (CSPGs) 1 …

It is well established that axonal regeneration in the adult CNS is largely unsuccessful.
Numerous axon‐inhibitory molecules are now known to be present in the injured CNS, and …