Chronopharmacology: new insights and therapeutic implications
Most facets of mammalian physiology and behavior vary according to time of day, thanks to
endogenous circadian clocks. Therefore, it is not surprising that many aspects of …
endogenous circadian clocks. Therefore, it is not surprising that many aspects of …
Dosing-time makes the poison: circadian regulation and pharmacotherapy
R Dallmann, A Okyar, F Lévi - Trends in molecular medicine, 2016 - cell.com
Daily rhythms in physiology significantly modulate drug pharmacokinetics and
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …
Circadian rhythms: mechanisms and therapeutic implications
F Levi, U Schibler - Annu. Rev. Pharmacol. Toxicol., 2007 - annualreviews.org
The mammalian circadian system is organized in a hierarchical manner in that a central
pacemaker in the suprachiasmatic nucleus (SCN) of the brain's hypothalamus synchronizes …
pacemaker in the suprachiasmatic nucleus (SCN) of the brain's hypothalamus synchronizes …
Chronopharmacological strategies focused on chrono-drug discovery
S Ohdo, S Koyanagi, N Matsunaga - Pharmacology & therapeutics, 2019 - Elsevier
In mammals, the circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN)
and influences a multitude of biological processes, including the sleep–wake rhythm …
and influences a multitude of biological processes, including the sleep–wake rhythm …
Chronopharmaceutics: pharmaceutics focused on biological rhythm
S Ohdo - Biological and Pharmaceutical Bulletin, 2010 - jstage.jst.go.jp
The circadian pacemaker of mammals resides in the paired suprachiasmatic nuclei (SCN)
and influences a multitude of biological processes, including the sleep-wake rhythm. Clock …
and influences a multitude of biological processes, including the sleep-wake rhythm. Clock …
The role of clock genes in pharmacology
GK Paschos, JE Baggs, JB Hogenesch… - Annual review of …, 2010 - annualreviews.org
The physiology of a wide variety of organisms is organized according to periodic
environmental changes imposed by the earth's rotation. This way, a large number of …
environmental changes imposed by the earth's rotation. This way, a large number of …
[HTML][HTML] Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions
VS Ayyar, S Sukumaran - Journal of pharmacokinetics and …, 2021 - Springer
Circadian rhythms are ubiquitous phenomena that recur daily in a self-sustaining,
entrainable, and oscillatory manner, and orchestrate a wide range of molecular …
entrainable, and oscillatory manner, and orchestrate a wide range of molecular …
Chronopharmacology focused on biological clock
S Ohdo - Drug metabolism and pharmacokinetics, 2007 - jstage.jst.go.jp
The mammalians circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN)
and in‰ uences a multitude of biological processes, including the sleep-wake rhythm. Clock …
and in‰ uences a multitude of biological processes, including the sleep-wake rhythm. Clock …
Chronotherapeutic strategy: rhythm monitoring, manipulation and disruption
S Ohdo - Advanced drug delivery reviews, 2010 - Elsevier
Mammalians circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN) and
influences a multitude of biological processes, including the sleep–wake rhythm. Clock …
influences a multitude of biological processes, including the sleep–wake rhythm. Clock …
Circadian regulation of drug responses: toward sex-specific and personalized chronotherapy
Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …