Chronopharmacology: new insights and therapeutic implications

R Dallmann, SA Brown, F Gachon - Annual review of …, 2014 - annualreviews.org
Most facets of mammalian physiology and behavior vary according to time of day, thanks to
endogenous circadian clocks. Therefore, it is not surprising that many aspects of …

Dosing-time makes the poison: circadian regulation and pharmacotherapy

R Dallmann, A Okyar, F Lévi - Trends in molecular medicine, 2016 - cell.com
Daily rhythms in physiology significantly modulate drug pharmacokinetics and
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …

Circadian rhythms: mechanisms and therapeutic implications

F Levi, U Schibler - Annu. Rev. Pharmacol. Toxicol., 2007 - annualreviews.org
The mammalian circadian system is organized in a hierarchical manner in that a central
pacemaker in the suprachiasmatic nucleus (SCN) of the brain's hypothalamus synchronizes …

Chronopharmacological strategies focused on chrono-drug discovery

S Ohdo, S Koyanagi, N Matsunaga - Pharmacology & therapeutics, 2019 - Elsevier
In mammals, the circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN)
and influences a multitude of biological processes, including the sleep–wake rhythm …

Chronopharmaceutics: pharmaceutics focused on biological rhythm

S Ohdo - Biological and Pharmaceutical Bulletin, 2010 - jstage.jst.go.jp
The circadian pacemaker of mammals resides in the paired suprachiasmatic nuclei (SCN)
and influences a multitude of biological processes, including the sleep-wake rhythm. Clock …

The role of clock genes in pharmacology

GK Paschos, JE Baggs, JB Hogenesch… - Annual review of …, 2010 - annualreviews.org
The physiology of a wide variety of organisms is organized according to periodic
environmental changes imposed by the earth's rotation. This way, a large number of …

[HTML][HTML] Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions

VS Ayyar, S Sukumaran - Journal of pharmacokinetics and …, 2021 - Springer
Circadian rhythms are ubiquitous phenomena that recur daily in a self-sustaining,
entrainable, and oscillatory manner, and orchestrate a wide range of molecular …

Chronopharmacology focused on biological clock

S Ohdo - Drug metabolism and pharmacokinetics, 2007 - jstage.jst.go.jp
The mammalians circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN)
and in‰ uences a multitude of biological processes, including the sleep-wake rhythm. Clock …

Chronotherapeutic strategy: rhythm monitoring, manipulation and disruption

S Ohdo - Advanced drug delivery reviews, 2010 - Elsevier
Mammalians circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN) and
influences a multitude of biological processes, including the sleep–wake rhythm. Clock …

Circadian regulation of drug responses: toward sex-specific and personalized chronotherapy

FA Lévi, A Okyar, E Hadadi… - Annual review of …, 2024 - annualreviews.org
Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …