Eicosapentaenoic acid (EPA): an antiinflammatory ω-3 fat with potential clinical applications

T Babcock, WS Helton, NJ Espat - Nutrition, 2000 - Elsevier
The potential benefit for including ω-3 (n-3) fatty acids in the normal diet has been supported
by clinical evidence of reduced cardiovascular disease for people consuming a diet …

Eicosapentaenoic acid supplementation reduces tumor volume and attenuates cachexia in a rat model of progressive non‐metastasizing malignancy

DH Jho, TA Babcock, R Tevar… - Journal of Parenteral …, 2002 - Wiley Online Library
BACKGROUND: Eicosapentaenoic acid (EPA) has been shown to have anti‐inflammatory
and tumor growth inhibitory effects clinically and experimentally; evidence also supports the …

Effect of oral eicosapentaenoic acid on weight loss in patients with pancreatic cancer

SJ Wigmore, MD Barber, JA Ross, MJ Tisdale… - Nutrition and …, 2000 - Taylor & Francis
Eicosapentaenoic acid (EPA) has been shown to modulate aspects of the inflammatory
response that may contribute to weight loss in cancer. This study aimed to evaluate the …

Eicosapentaenoic acid in cancer improves body composition and modulates metabolism

G Pappalardo, A Almeida, P Ravasco - Nutrition, 2015 - Elsevier
Objectives The objective of this review article is to present the most recent intervention
studies with EPA on nutritional outcomes in cancer patients, eg nutritional status, weight & …

Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia

KCH Fearon, MD Barber, AG Moses… - Journal of Clinical …, 2006 - ascopubs.org
Purpose Eicosapentaenoic acid (EPA) has been proposed to have specific anticachectic
effects. This trial compared EPA diethyl ester with placebo in cachectic cancer patients for …

Omega‐3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

PC Calder - British journal of clinical pharmacology, 2013 - Wiley Online Library
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are n‐3 fatty acids found in
oily fish and fish oil supplements. These fatty acids are able to inhibit partly a number of …

Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids

R Wall, RP Ross, GF Fitzgerald, C Stanton - Nutrition reviews, 2010 - academic.oup.com
Abstract Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFA) are
precursors of potent lipid mediators, termed eicosanoids, which play an important role in the …

Omega-3 fatty acids and inflammation

TA Mori, LJ Beilin - Current atherosclerosis reports, 2004 - Springer
Abstract Dietary omega-3 (n-3) fatty acids have a variety of anti-inflammatory and immune-
modulating effects that may be of relevance to atherosclerosis and its clinical manifestations …

Influence of eicosapentaenoic acid supplementation on lean body mass in cancer cachexia

RA Murphy, E Yeung, VC Mazurak… - British journal of …, 2011 - nature.com
Cancer cachexia is characterised by a progressive loss of muscle, resulting in functional
impairment and shorter survival. Eicosapentaenoic acid, an n-3 polyunsaturated fatty acid …

Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation

RS Chapkin, W Kim, JR Lupton… - … Leukotrienes and Essential …, 2009 - Elsevier
The inflammatory response is designed to help fight and clear infection, remove harmful
chemicals, and repair damaged tissue and organ systems. Although this process, in general …