[HTML][HTML] Multifaceted Functions and Novel Insight Into the Regulatory Role of RNA N6-Methyladenosine Modification in Musculoskeletal Disorders

W Zhang, L He, Z Liu, X Ren, L Qi, L Wan… - Frontiers in Cell and …, 2020 - frontiersin.org
RNA modifications have emerged as key regulators of transcript expression in diverse
physiological and pathological processes. As one of the most prevalent types of RNA …

RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation

Y Yue, J Liu, C He - Genes & development, 2015 - genesdev.cshlp.org
N 6-methyladenosine (m6A) is the most prevalent and internal modification that occurs in the
messenger RNAs (mRNA) of most eukaryotes, although its functional relevance remained a …

[HTML][HTML] Targeted Demethylation of the TGFβ1 mRNA Promotes Myoblast Proliferation via Activating the SMAD2 Signaling Pathway

K Deng, Z Liu, X Li, Z Zhang, Y Fan, Q Huang, Y Zhang… - Cells, 2023 - mdpi.com
Recent evidence suggested that N6-methyladenosine (m6A) methylation can determine
m6A-modified mRNA fate and play an important role in skeletal muscle development. It was …

N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases

Y Chen, X Ouyang, X Yu, P Novák, L Zhou… - Journal of …, 2021 - Springer
Abstract N6-methyladenosine (m 6 A) is the most abundant and prevalent epigenetic
modification of mRNA in mammals. This dynamic modification is regulated by m 6 A …

Insights into the N6-methyladenosine mechanism and its functionality: progress and questions

M Scarrow, N Chen, G Sun - Critical reviews in biotechnology, 2020 - Taylor & Francis
Abstract N6-methyladenosine (m6A) RNA methylation has become a progressively popular
area of molecular research since the discovery of its potentially essential regulatory role …

[HTML][HTML] m6A Methylases Regulate Myoblast Proliferation, Apoptosis and Differentiation

X Yang, C Mei, X Ma, J Du, J Wang, L Zan - Animals, 2022 - mdpi.com
Simple Summary N 6-methyladenosine (m6A) is the most prevalent methylation modification
in eukaryotic mRNA, and it plays an important role in regulating gene expression. Previous …

N6-methyladenosine-mediated gene regulation and therapeutic implications

Y Liu, D Yang, T Liu, J Chen, J Yu, P Yi - Trends in molecular medicine, 2023 - cell.com
Abstract N6-methyladenosine (m 6 A) RNA methylation is the most abundant form of mRNA
modification in eukaryotes and is at the front line of biological and biomedical research. This …

[HTML][HTML] METTL3 Promotes the Differentiation of Goat Skeletal Muscle Satellite Cells by Regulating MEF2C mRNA Stability in am6A-Dependent Manner

S Zhao, J Cao, Y Sun, H Zhou, Q Zhu, D Dai… - International journal of …, 2023 - mdpi.com
The development of mammalian skeletal muscle is a highly complex process involving
multiple molecular interactions. As a prevalent RNA modification, N6-methyladenosine …

Regulatory Role of N6‐methyladenosine (m6A) Methylation in RNA Processing and Human Diseases

W Wei, X Ji, X Guo, S Ji - Journal of Cellular Biochemistry, 2017 - Wiley Online Library
ABSTRACT N6‐methyladenosine (m6A) modification is an abundant and conservative RNA
modification in bacterial and eukaryotic cells. m6A modification mainly occurs in the 3 …

The biogenesis and precise control of RNA m6A methylation

H Huang, H Weng, J Chen - Trends in Genetics, 2020 - cell.com
N 6-Methyladenosine (m 6 A) is the most prevalent internal RNA modification in mRNA, and
has been found to be highly conserved and hard-coded in mammals and other eukaryotic …