Until recently, the ability of ARF (human p14 ARF, murine p19 ARF) tumour-suppressor
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …

The tumor suppressor ARF is transcribed from the INK4a/ARF locus in partly overlapping
reading frames with the CDK inhibitor p16 Ink4a. ARF is able to antagonize the MDM2 …

The tumor suppressor p19Arf (p14ARF in humans), encoded by the Ink4a/Arf locus, is
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …

Abstract p19 ARF encoded by the INK4a tumor suppressor gene locus functions upstream of
p53 to induce cell cycle arrest. p19 ARF can interact with MDM2 and p53 in cells ectopically …

Abstract The Ink4a-Arf locus encodes two closely wedded tumor suppressor proteins (p16
Ink4a and p19 Arf) that inhibit cell proliferationby activating Rb and p53, respectively. With …

The human INK4a locus encodes two structurally unrelated tumor suppressor proteins, p16
INK4a and p14 ARF (p19 ARF in the mouse), which are frequently inactivated in human …

Abstract P14/p19 ARF (ARF) plays a major role in the activation of p53 by oncogenic
signals. The biochemical basis of this has not been fully elucidated. We report here that …

The INK4a-ARF locus encodes two proteins, p16INK4a and p19ARF, that restrain cell
growth by affecting the functions of the retinoblastoma protein and p53, respectively …

The human INK4a gene locus encodes two structurally unrelated tumor suppressor proteins,
p16 INK4a and p14 ARF, which are frequently inactivated in human cancer. Whereas p16 …

The human INK4a gene locus encodes two structurally unrelated tumor suppressor proteins,
p16 INK4a and p14 ARF. Although primarily proposed to require a functional p53· Mdm-2 …