Memantine inhibits calpain-mediated truncation of GSK-3 induced by NMDA: implications in Alzheimer's disease
P Goni-Oliver, J Avila… - Journal of Alzheimer's …, 2009 - content.iospress.com
Deregulation of glycogen synthase kinase-3 (GSK-3) activity is believed to play a key role in
the pathogenesis of Alzheimer's disease (AD). GSK-3 activity is regulated by …
the pathogenesis of Alzheimer's disease (AD). GSK-3 activity is regulated by …
In vivo regulation of GSK3 phosphorylation by cholinergic and NMDA receptors
P De Sarno, GN Bijur, AA Zmijewska, X Li… - Neurobiology of aging, 2006 - Elsevier
Glycogen synthase kinase-3 (GSK3), which is inhibited by serine-phosphorylation, is
involved in the neuropathology of Alzheimer's disease (AD). We tested if the two therapeutic …
involved in the neuropathology of Alzheimer's disease (AD). We tested if the two therapeutic …
Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease
Alzheimer's disease (AD) is a disorder without a molecular marker in peripheral tissues or a
disease modifying treatment. As increasing evidence has suggested a role for glycogen …
disease modifying treatment. As increasing evidence has suggested a role for glycogen …
The GSK3 hypothesis of Alzheimer's disease
C Hooper, R Killick, S Lovestone - Journal of neurochemistry, 2008 - Wiley Online Library
J. Neurochem.(2008) 104, 1433–1439. Abstract Glycogen synthase kinase 3 (GSK3) is a
constitutively active, proline‐directed serine/threonine kinase that plays a part in a number of …
constitutively active, proline‐directed serine/threonine kinase that plays a part in a number of …
GSK‐3: A key player in neurodegeneration and memory
KP Giese - IUBMB life, 2009 - Wiley Online Library
Abnormalities in molecular signalling have been implicated in neurodegeneration. It is
emerging that glycogen synthase kinase‐3 (GSK‐3) is a key signalling molecule that …
emerging that glycogen synthase kinase‐3 (GSK‐3) is a key signalling molecule that …
Regulation of Cell Survival Mechanisms in Alzheimer′ s Disease by Glycogen Synthase Kinase‐3
A pivotal role has emerged for glycogen synthase kinase‐3 (GSK3) as an important
contributor to Alzheimer′ s disease pathology. Evidence for the involvement of GSK3 in …
contributor to Alzheimer′ s disease pathology. Evidence for the involvement of GSK3 in …
Glycogen synthase kinase-3 in neurodegeneration and neuroprotection: lessons from lithium
S Yadranji Aghdam, SW Barger - Current Alzheimer Research, 2007 - ingentaconnect.com
For over fifty years lithium has been a fundamental component of therapy for patients with
bipolar disorders. Lithium has been considered recently for its potential to alleviate neuronal …
bipolar disorders. Lithium has been considered recently for its potential to alleviate neuronal …
β-Amyloid impairs the regulation of N-methyl-D-aspartate receptors by glycogen synthase kinase 3
Accumulating evidence suggests that glycogen synthase kinase 3 (GSK-3) is a
multifunctional kinase implicated in Alzheimer's disease (AD). However, the synaptic actions …
multifunctional kinase implicated in Alzheimer's disease (AD). However, the synaptic actions …
New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease
M Medina, J Avila - Expert opinion on therapeutic targets, 2014 - Taylor & Francis
Introduction: Glycogen synthase kinase-3 (GSK-3) is recognized as a crucial player in many
cellular functions and its activity is tightly controlled by complex mechanisms that are each …
cellular functions and its activity is tightly controlled by complex mechanisms that are each …
[HTML][HTML] Glycogen synthase kinase-3 signaling in Alzheimer's disease
E Lauretti, O Dincer, D Praticò - … et Biophysica Acta (BBA)-Molecular Cell …, 2020 - Elsevier
Alzheimer's disease (AD) is the most common form of neurodegenerative disorder with
dementia, accounting for approximately 70% of the all cases. Currently, 5.8 million people in …
dementia, accounting for approximately 70% of the all cases. Currently, 5.8 million people in …