Cleavage of GSK‐3β by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK‐3β activity induced by H2O2
Y Feng, Y Xia, G Yu, X Shu, H Ge, K Zeng… - Journal of …, 2013 - Wiley Online Library
Glycogen synthase kinase‐3 beta (GSK‐3β) dysfunction may play an essential role in the
pathogenesis of psychiatric, metabolic, neurodegenerative diseases, in which oxidative …
pathogenesis of psychiatric, metabolic, neurodegenerative diseases, in which oxidative …
Glycogen synthase kinase 3: a drug target for CNS therapies
RV Bhat, SL Budd Haeberlein… - Journal of …, 2004 - Wiley Online Library
Abstract Glycogen synthase kinase3 (GSK3) is emerging as a prominent drug target in the
CNS. The most exciting of the possibilities of GSK3 lies within the treatment of Alzheimer's …
CNS. The most exciting of the possibilities of GSK3 lies within the treatment of Alzheimer's …
Dynamic range of GSK3α not GSK3β is essential for bidirectional synaptic plasticity at hippocampal CA3‐CA1 synapses
L Shahab, F Plattner, EE Irvine, DM Cummings… - …, 2014 - Wiley Online Library
ABSTRACT Glycogen synthase kinase‐3 (GSK3), particularly the isoform GSK3β, has been
implicated in a wide range of physiological systems and neurological disorders including …
implicated in a wide range of physiological systems and neurological disorders including …
Glycogen synthase kinase-3 as a key regulator of cognitive function
X Fan, Z Zhao, D Wang, J Xiao - Acta biochimica et biophysica …, 2020 - academic.oup.com
Abstract Glycogen synthase kinase-3 (GSK-3) is a highly conserved and multifunctional
serine/threonine protein kinase widely distributed in eukaryotic cells. GSK-3 is originally …
serine/threonine protein kinase widely distributed in eukaryotic cells. GSK-3 is originally …
Glycogen synthase kinase 3 (GSK3): its role and inhibitors
Glycogen Synthase Kinase 3 (GSK3) is one of the Serine/Threonine protein kinases, which
has gained a lot of attention for its role in a variety of pathways. It has two isoforms, GSK3α …
has gained a lot of attention for its role in a variety of pathways. It has two isoforms, GSK3α …
Glycogen synthase kinase‐3 inhibition is integral to long‐term potentiation
C Hooper, V Markevich, F Plattner… - European journal of …, 2007 - Wiley Online Library
Abstract Glycogen synthase kinase‐3 (GSK‐3) is a serine/threonine kinase regulating
diverse cellular functions including metabolism, transcription and cell survival. Numerous …
diverse cellular functions including metabolism, transcription and cell survival. Numerous …
[HTML][HTML] GSK3β Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons
G Cuesto, S Jordán-Álvarez, L Enriquez-Barreto… - PloS one, 2015 - journals.plos.org
The PI3K-dependent activation of AKT results in the inhibition of GSK3β in most signaling
pathways. These kinases regulate multiple neuronal processes including the control of …
pathways. These kinases regulate multiple neuronal processes including the control of …
[HTML][HTML] New insights into the role of GSK-3β in the brain: from neurodegenerative disease to tumorigenesis
S Lai, P Wang, J Gong, S Zhang - PeerJ, 2023 - peerj.com
Abstract Glycogen synthase kinase 3 (GSK-3) is a serine/threonine kinase widely expressed
in various tissues and organs. Unlike other kinases, GSK-3 is active under resting conditions …
in various tissues and organs. Unlike other kinases, GSK-3 is active under resting conditions …
The role of GSK‐3 in synaptic plasticity
S Peineau, C Bradley, C Taghibiglou… - British journal of …, 2008 - Wiley Online Library
Glycogen synthase kinase‐3 (GSK‐3), an important component of the glycogen metabolism
pathway, is highly expressed in the CNS. It has been implicated in major neurological …
pathway, is highly expressed in the CNS. It has been implicated in major neurological …
Glycogen synthase kinase-3 as a therapeutic target for cognitive dysfunction in neuropsychiatric disorders
The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) is involved in a broad
range of cellular processes including cell proliferation, apoptosis and inflammation. It is now …
range of cellular processes including cell proliferation, apoptosis and inflammation. It is now …