The tumor microenvironment consists of tumor, immune, stromal, and inflammatory cells
which produce cytokines, growth factors, and adhesion molecules that promote tumor …

Interleukin-1 (IL-1) comprises a family of closely related genes; the two major agonistic
proteins, IL-1α and IL-1β, are pleiotropic and affect mainly inflammation, immunity and …

Interleukin-1 (IL-1) represents a family of two agonistic proteins, IL-1α and IL-1β, that are
pleiotropic and affect hemopoiesis, inflammation, and immunity. In the context of the …

Summary Interleukin-1 (IL-1) is a key orchestrator of inflammation and plays an important
role in tumor progression. Based on preclinical models and human genetic associations, we …

Abstract Interleukin-1 (IL-1) includes a family of closely related genes; the two major
agonistic proteins, IL-1α and IL-1β, are pleiotropic and affect mainly inflammation, immunity …

Abstract BACKGROUND: Interleukin 1 (IL-1) is a pluripotent cytokine that promotes
angiogenesis, tumor growth, and metastasis in experimental models; its presence in some …

Tumor progression relies on the ability of cancer cells to effectively invade surrounding
tissues and propagate. Among the many mechanisms that contribute to tumor progression is …

The interleukin‐1 (IL‐1) family consists of two major agonistic proteins, IL‐1α and IL‐1β,
which are pleiotropic and affect mainly inflammation, immunity, and hemopoiesis. The IL‐1 …

The aggressive nature of metastatic human cancer has been shown to be related to
numerous abnormalities in growth factors and their receptors. These perturbations confer a …

Here, we describe that microenvironmental IL-1β and, to a lesser extent, IL-1α are required
for in vivo angiogenesis and invasiveness of different tumor cells. In IL-1β knockout (KO) …