Introduction Maternal elevated plasma total homocysteine (tHcy) is involved in the origin of
several placenta-related pregnancy complications. The first trimester is the most sensitive …

Homocysteine is a marker for derangements in one-carbon metabolism. Elevated
homocysteine may represent a causal link between poor maternal nutrition and impaired …

Background Placenta-mediated pregnancy complications (PMPCs) are a significant
contributor to adverse maternal and fetal outcomes. Though the exact cause of the array of …

Background Homocysteine is an intermediate metabolite implicated in the risk of placenta-
mediated complications, including preeclampsia, placental abruption, fetal growth …

The most extremely unfavourable outcome of pregnancy is the death of the mother and
newborn. Negative outcomes for mothers or babies can occur as a result of complications or …

Methionine demethylation during metabolism generates homocysteine (Hcy) and its
remethylation requires folate and cobalamin. Elevated Hcy concentrations are associated …

Please cite this paper as: Bergen N, Jaddoe V, Timmermans S, Hofman A, Lindemans J,
Russcher H, Raat H, Steegers‐Theunissen R, Steegers E. Homocysteine and folate …

Background: Increased total homocysteine (tHcy) may be associated with placental-
mediated adverse pregnancy outcomes, but few prospective studies have measured tHcy …

Objective: To measure fetal and maternal plasma homocysteine (Hcy) concentrations in
uncomplicated pregnancies. Methods: Paired maternal venous and fetal umbilical cord …

Total fasting plasma homocysteine (tHcy) is significantly reduced during early–mid normal
pregnancy. Elevated tHcy during or outside of pregnancy has been associated with adverse …