Heterogeneity of fibroblasts and myofibroblasts in pulmonary fibrosis

DM Habiel, CM Hogaboam - Current pathobiology reports, 2017 - Springer
Abstract Purpose of Review Idiopathic pulmonary fibrosis (IPF) is the most common form of
interstitial lung disease of unknown etiopathogenesis with mean survival of 3–5 years and …

Novel differences in gene expression and functional capabilities of myofibroblast populations in idiopathic pulmonary fibrosis

SM Walsh, JC Worrell, A Fabre… - … of Physiology-Lung …, 2018 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF), a chronic progressive interstitial pneumonia, is
characterized by excessive fibroproliferation. Key effector cells in IPF are myofibroblasts that …

[HTML][HTML] Regulation and relevance of myofibroblast responses in idiopathic pulmonary fibrosis

MW Moore, EL Herzog - Current pathobiology reports, 2013 - Springer
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, incurable lung disease of
unknown etiology with only limited treatment options. Current paradigms of disease …

[HTML][HTML] Two-way conversion between lipogenic and myogenic fibroblastic phenotypes marks the progression and resolution of lung fibrosis

E El Agha, A Moiseenko, V Kheirollahi, S De Langhe… - Cell stem cell, 2017 - cell.com
Idiopathic pulmonary fibrosis (IPF) is a form of progressive interstitial lung disease with
unknown etiology. Due to a lack of effective treatment, IPF is associated with a high mortality …

Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers

M Selman, A Pardo - Proceedings of the American Thoracic Society, 2006 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF), a progressive and relentless lung scarring of unknown
etiology, has been recognized as the most lethal interstitial lung disease. Despite the …

Epithelial origin of myofibroblasts during fibrosis in the lung

BC Willis, RM duBois, Z Borok - Proceedings of the American …, 2006 - atsjournals.org
An understanding of the mechanisms underlying pulmonary fibrosis remains elusive. Once
believed to result primarily from chronic inflammation, it is now clear that inflammation and …

Molecular targets in pulmonary fibrosis: the myofibroblast in focus

CJ Scotton, RC Chambers - Chest, 2007 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is one of a group of interstitial lung diseases that are
characterized by excessive matrix deposition and destruction of the normal lung …

[HTML][HTML] Identification of a cell-of-origin for fibroblasts comprising the fibrotic reticulum in idiopathic pulmonary fibrosis

H Xia, V Bodempudi, A Benyumov, P Hergert… - The American journal of …, 2014 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive disease of the middle aged and elderly
with a prevalence of one million persons worldwide. The fibrosis spreads from affected …

[HTML][HTML] Heterogeneity in fibroblast proliferation and survival in idiopathic pulmonary fibrosis

DM Habiel, C Hogaboam - Frontiers in pharmacology, 2014 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease
characterized by the persistence of activated myofibroblasts resulting in excessive …

Cloning a profibrotic stem cell variant in idiopathic pulmonary fibrosis

S Wang, W Rao, A Hoffman, J Lin, J Li, T Lin… - Science translational …, 2023 - science.org
Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and rapidly fatal interstitial
lung disease marked by the replacement of lung alveoli with dense fibrotic matrices …