Cortical mechanisms of loss of consciousness: insight from TMS/EEG studies

M Massimini, F Ferrarelli, S Sarasso… - Archives italiennes de …, 2012 - architalbiol.org
In a recent series of experiments we recorded the electroencephalogram (EEG) response to
a direct cortical stimulation in humans during wakefulness, NREM sleep, REM sleep and …

Why does consciousness fade in early sleep?

G Tononi, M Massimini - Annals of the New York Academy of …, 2008 - Wiley Online Library
Consciousness fades during deep nonrapid eye movement (NREM) sleep early in the night,
yet cortical neurons remain active, keep receiving sensory inputs, and can display patterns …

Cortical reactivity and effective connectivity during REM sleep in humans

M Massimini, F Ferrarelli, MJ Murphy… - Cognitive …, 2010 - Taylor & Francis
We recorded the electroencephalographic (EEG) responses evoked by transcranial
magnetic stimulation (TMS) during the first rapid eye movement (REM) sleep episode of the …

Quantifying cortical EEG responses to TMS in (un) consciousness

S Sarasso, M Rosanova, AG Casali… - Clinical EEG and …, 2014 - journals.sagepub.com
We normally assess another individual's level of consciousness based on her or his ability to
interact with the surrounding environment and communicate. Usually, if we observe …

Consciousness and cortical responsiveness: a within-state study during non-rapid eye movement sleep

JO Nieminen, O Gosseries, M Massimini, E Saad… - Scientific Reports, 2016 - nature.com
When subjects become unconscious, there is a characteristic change in the way the cerebral
cortex responds to perturbations, as can be assessed using transcranial magnetic …

Time-frequency analysis of short-lasting modulation of EEG induced by TMS during wake, sleep deprivation and sleep

P Manganotti, E Formaggio, A Del Felice… - Frontiers in human …, 2013 - frontiersin.org
The occurrence of dynamic changes in spontaneous electroencephalogram (EEG) rhythms
in the awake state or sleep is highly variable. These rhythms can be externally modulated …

Human cortical excitability increases with time awake

R Huber, H Mäki, M Rosanova, S Casarotto… - Cerebral …, 2013 - academic.oup.com
Prolonged wakefulness is associated not only with obvious changes in the way we feel and
perform but also with well-known clinical effects, such as increased susceptibility to seizures …

Slow waves, synaptic plasticity and information processing: insights from transcranial magnetic stimulation and high‐density EEG experiments

M Massimini, G Tononi, R Huber - European Journal of …, 2009 - Wiley Online Library
Sleep slow waves are the main phenomenon underlying NREM sleep. They are
homeostatically regulated, they are thought to be linked to learning and plasticity processes …

Involvement of the thalamocortical system in epileptic loss of consciousness

GK Kostopoulos - Epilepsia, 2001 - Wiley Online Library
Experiments on putative neuronal mechanisms underlying absence seizures as well as
clinical observations are critically reviewed for their ability to explain apparent “loss of …

Cortical plasticity induced by transcranial magnetic stimulation during wakefulness affects electroencephalogram activity during sleep

L De Gennaro, F Fratello, C Marzano, F Moroni… - PloS one, 2008 - journals.plos.org
Background Sleep electroencephalogram (EEG) brain oscillations in the low-frequency
range show local signs of homeostatic regulation after learning. Such increases and …