The critical role of Akt in cardiovascular function

P Abeyrathna, Y Su - Vascular pharmacology, 2015 - Elsevier
Akt kinase, a member of AGC kinases, is important in many cellular functions including
proliferation, migration, cell growth and metabolism. There are three known Akt isoforms …

Role of Akt signaling in vascular homeostasis and angiogenesis

I Shiojima, K Walsh - Circulation research, 2002 - Am Heart Assoc
Akt is a serine/threonine protein kinase that is activated by a number of growth factors and
cytokines in a phosphatidylinositol-3 kinase–dependent manner. Although antiapoptotic …

Akt1 in endothelial cell and angiogenesis

PR Somanath, OV Razorenova, J Chen, TV Byzova - Cell cycle, 2006 - Taylor & Francis
Akt, also known as Protein kinase B (PKB), regulates essential cellular functions such as
migration, proliferation, differentiation, apoptosis, and metabolism. Akt influences the …

[HTML][HTML] Akt isoforms in vascular disease

H Yu, T Littlewood, M Bennett - Vascular pharmacology, 2015 - Elsevier
The mammalian serine/threonine Akt kinases comprise three closely related isoforms: Akt1,
Akt2 and Akt3. Akt activation has been implicated in both normal and disease processes …

[HTML][HTML] Akt1 in the cardiovascular system: friend or foe?

BT O'Neill, ED Abel - The Journal of clinical investigation, 2005 - Am Soc Clin Investig
Akt is an important signaling molecule that modulates many cellular processes such as cell
growth, survival, and metabolism. Akt activation has been proposed as a potential strategy …

AKT signaling in regulating angiogenesis

BH Jiang, LZ Liu - Current cancer drug targets, 2008 - ingentaconnect.com
AKT is a central signaling molecule in regulating cell survival, proliferation, tumor growth
and angiogenesis. Upstream components of AKT signaling pathway such as PI3K, PTEN …

Akt signaling and growth of the heart

K Walsh - Circulation, 2006 - Am Heart Assoc
Physiological cardiac growth is a feature of normal postnatal development in which an
increase in cardiac muscle cell diameter is observed as infants mature to adults. 1 This …

Akt signalling in health and disease

I Hers, EE Vincent, JM Tavaré - Cellular signalling, 2011 - Elsevier
Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1,
Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the …

Akt3 overexpression in the heart results in progression from adaptive to maladaptive hypertrophy

Y Taniyama, M Ito, K Sato, C Kuester, K Veit… - Journal of molecular and …, 2005 - Elsevier
Akt is a serine/threonine kinase that mediates a variety of cellular responses to external
stimuli. Among the three members of mammalian Akt (Akt1, Akt2 and Akt3), Akt3 is unique in …

[HTML][HTML] Akt signaling in macrophage polarization, survival, and atherosclerosis

MRF Linton, JJ Moslehi, VR Babaev - International journal of molecular …, 2019 - mdpi.com
The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of
macrophages, which may impact the development of atherosclerosis. Changes in Akt …