Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly

DA Gordon, H Jamil - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2000 - Elsevier
The microsomal triglyceride transfer protein (MTP) is necessary for the proper assembly of
the apolipoprotein B containing lipoproteins, very low density lipoprotein and chylomicrons …

Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the …

DA Gordon, H Jamil, RE Gregg, SO Olofsson… - Journal of Biological …, 1996 - ASBMB
The microsomal triglyceride transfer protein (MTP) is required for assembly and secretion of
the lipoproteins containing apolipoprotein B (apoB): very low density lipoproteins and …

The microsomal triglyceride transfer protein catalyzes the post-translational assembly of apolipoprotein B-100 very low density lipoprotein in McA-RH7777 cells

S Rustaeus, P Stillemark, K Lindberg, D Gordon… - Journal of Biological …, 1998 - ASBMB
In cells in which the lipoprotein assembly process had been inactivated by brefeldin A (BFA),
membrane-associated apoB-100 disappeared without forming lipoproteins or being …

The microsomal triglyceride transfer protein facilitates assembly and secretion of apolipoprotein B-containing lipoproteins and decreases cotranslational degradation …

S Wang, RS McLeod, DA Gordon, Z Yao - Journal of Biological Chemistry, 1996 - ASBMB
We studied the role of microsomal triglyceride transfer protein (MTP) in the synthesis,
secretion, and cotranslational degradation of apolipoprotein (apo) B using nonhepatic COS …

Recent advances in elucidating the role of the microsomal triglyceride transfer protein in apolipoprotein B lipoprotein assembly

DA Gordon - Current opinion in lipidology, 1997 - journals.lww.com
The microsomal triglyceride transfer protein is necessary for the assembly and secretion of
lipoproteins containing apolipoprotein B. During the past year, significant progress has been …

The activity of microsomal triglyceride transfer protein is essential for accumulation of triglyceride within microsomes in McA-RH7777 cells: a unified model for the …

Y Wang, K Tran, Z Yao - Journal of Biological Chemistry, 1999 - ASBMB
Previously, based on distinct requirement of microsomal triglyceride transfer protein (MTP)
and kinetics of triglyceride (TG) utilization, we concluded that assembly of very low density …

Demonstration of a Physical Interaction between Microsomal Triglyceride Transfer Protein and Apolipoprotein B during the Assembly of ApoB-containing Lipoproteins …

X Wu, M Zhou, LS Huang, J Wetterau… - Journal of Biological …, 1996 - ASBMB
Microsomal triglyceride (TG) transfer protein (MTP) is an endoplasmic reticulum lumenal
protein consisting of a 97-kDa subunit and protein disulfide isomerase. It is believed that …

Apolipoprotein B binding to microsomal triglyceride transfer protein decreases with increases in length and lipidation: implications in lipoprotein biosynthesis

MM Hussain, A Bakillah, H Jamil - Biochemistry, 1997 - ACS Publications
Microsomal triglyceride transfer protein (MTP), a heterodimer of 97 kDa and protein disulfide
isomerase, is required for the assembly of apolipoprotein B (apoB)-containing triglyceride …

Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly

MM Hussain, J Shi, P Dreizen - Journal of lipid research, 2003 - ASBMB
Apolipoprotein B (ap1111190) and microsomal triglyceride transfer protein (MTP) are
necessary for lipoprotein assembly. ApoB consists of five structural domains, βα 1-β 1-α 2-β …

Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by …

DA Gordon, H Jamil, D Sharp… - Proceedings of the …, 1994 - National Acad Sciences
To elucidate the role of the microsomal triglyceride transfer protein (MTP) in lipoprotein
assembly, MTP and apolipoprotein B-53 (apoB 53; the N-terminal 53% of apoB) were …