At the time of this writing, a major void exists; the lack of a method to prevent and/or reverse
type 1 diabetes in humans. We believe this void to a large extent is the result of our lack in …

Regulatory T cells (Tregs) are critical regulators of peripheral immune tolerance. Treg
insufficiency can lead to autoimmune disorders, including type 1 diabetes (T1D). Increasing …

In this brief review we propose to discuss salient data showing the importance of immune
regulatory mechanisms, and in particular of Treg, for the control of pathogenic anti-β-cell …

Summary Type 1 diabetes (T1D) is a T‐cell‐mediated autoimmune disease resulting in islet
β‐cell destruction, hypoinsulinaemia and severely altered glucose homeostasis. Although …

Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease affecting millions of people
worldwide. The disease is characterized by the loss of self-tolerance to the insulin-producing …

In recent years, there has been a revival of the concept of CD4+ regulatory T (Treg) cells as
being a central control point in various immune responses, including autoimmune …

Studies on human type 1 diabetes (T1D) are facilitated by the availability of animal models
such as nonobese diabetic (NOD) mice that spontaneously develop autoimmune diabetes …

There is increasing evidence that dysregulated immune responses play key roles in the
pathogenesis and complications of type 1 but also type 2 diabetes. Indeed, chronic …

Revisiting regulatory T cells in type 1 diabetes : Current Opinion in Endocrinology, Diabetes
and Obesity Revisiting regulatory T cells in type 1 diabetes : Current Opinion in …

Type 1 diabetes mellitus (T1DM) is a T cell-mediated autoimmune disease characterized by
the destruction of pancreatic β cells. Numerous studies have demonstrated the key role of …