Molecular targets and anticancer potential of sanguinarine—A benzophenanthridine alkaloid

S Galadari, A Rahman, S Pallichankandy… - Phytomedicine, 2017 - Elsevier
Background Cancer is an enormous global health burden, and should be effectively
addressed with better therapeutic strategies. Currently, over 60% of the clinically approved …

Anticancer potential of sanguinarine for various human malignancies

IW Achkar, F Mraiche, RM Mohammad… - Future medicinal …, 2017 - Taylor & Francis
Sanguinarine (Sang)–a benzophenanthridine alkaloid extracted from Sanguinaria
canadensis–exhibits antioxidant, anti-inflammatory, proapoptotic and growth inhibitory …

[HTML][HTML] Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

R Gaziano, G Moroni, C Buè, MT Miele… - World Journal of …, 2016 - ncbi.nlm.nih.gov
Historically, natural products have represented a significant source of anticancer agents,
with plant-derived drugs becoming increasingly explored. In particular, sanguinarine is a …

Molecular mechanisms of Sanguinarine in cancer prevention and treatment

A Ullah, N Ullah, T Nawaz, T Aziz - Anti-Cancer Agents in …, 2023 - ingentaconnect.com
Historically, natural plant-derived drugs received a great impact of consideration in the
treatment of several human-associated disorders. Cancer is a devastating disease and the …

[HTML][HTML] Bioactivity and mechanism of action of sanguinarine and its derivatives in the past 10 years

LJ Huang, JX Lan, JH Wang, H Huang, K Lu… - Biomedicine & …, 2024 - Elsevier
Sanguinarine is a quaternary ammonium benzophenanthine alkaloid found in traditional
herbs such as Chelidonium, Corydalis, Sanguinarum, and Borovula. It has been proven to …

Antitumour activities of sanguinarine and related alkaloids

I Slaninová, K Pěnčíková, J Urbanová, J Slanina… - Phytochemistry …, 2014 - Springer
Sanguinarine is a best-known member of a relatively small group of quaternary benzo [c]
phenanthridine alkaloids (QBAs). QBAs are widely distributed in the family Papaveraceae …

Sanguinarine inhibits growth of human cervical cancer cells through the induction of apoptosis

JY Xu, QH Meng, Y Chong, Y Jiao… - Oncology …, 2012 - spandidos-publications.com
Sanguinarine, a natural benzophenanthridine alkaloid, has been shown to possess
anticancer activity in vitro and in vivo. In the present study, we demonstrated that …

Sanguinarine inhibits the proliferation of BGC-823 gastric cancer cells via regulating miR-96-5p/miR-29c-3p and the MAPK/JNK signaling pathway

XZ Dong, Y Song, YP Lu, Y Hu, P Liu… - Journal of natural …, 2019 - Springer
Sanguinarine (SAN), a quaternary benzophenanthridine alkaloid extracted from the root of
Papaveraceae plants, has shown antitumour effects in multiple cancer cells. However, the …

Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through …

MH Han, SO Kim, GY Kim, TK Kwon, BT Choi… - Anti-cancer …, 2007 - journals.lww.com
Sanguinarine is a benzophenanthridine alkaloid that is derived from the root of Sanguinaria
canadensis and other poppy fumaria species, and is known to have antimicrobial …

Sanguinarine and its role in chronic diseases

P Basu, GS Kumar - Anti-inflammatory nutraceuticals and chronic diseases, 2016 - Springer
The use of natural products derived from plants as medicines precedes even the recorded
human history. In the past few years there were renewed interests in developing natural …