Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons

U Oh, SW Hwang, D Kim - Journal of Neuroscience, 1996 - Soc Neuroscience
Capsaicin (CAP), a neurotoxin, has been reported to activate a nonselective cation current
in dorsal root ganglion (DRG) neurons. In this paper, we identify and describe the properties …

Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel

J Jung, SW Hwang, J Kwak, SY Lee… - Journal of …, 1999 - Soc Neuroscience
Capsaicin (CAP) excites small sensory neurons, causing pain, neurogenic inflammation,
and other visceral reflexes. These effects have been proposed to be the result of CAP …

The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons

PA Koplas, RL Rosenberg, GS Oxford - Journal of Neuroscience, 1997 - Soc Neuroscience
Capsaicin (Cap) is a pungent extract of the Capsicum pepper family, which activates
nociceptive primary sensory neurons. Inward current and membrane potential responses of …

Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats

RJ Docherty, JC Yeats, S Bevan, H Boddeke - Pflügers Archiv, 1996 - Springer
Capsaicin activates a non-specific cation conductance in mammalian sensory neurones. If
capsaicin is applied continuously or repeatedly then there is a progressive decline in …

Capsaicin causes prolonged inhibition of voltage-activated calcium currents in adult rat dorsal root ganglion neurons in culture

RJ Docherty, B Robertson, S Bevan - Neuroscience, 1991 - Elsevier
The effect of capsaicin on voltage-activated calcium currents was investigated in
voltageclamped somata of cultured adult rat dorsal root ganglion neurons. About half the …

Inflammatory mediators at acidic pH activate capsaicin receptors in cultured sensory neurons from newborn rats

L Vyklický, H Knotková-Urbancová… - Journal of …, 1998 - journals.physiology.org
Vyklický, Ladislav, Helena Knotková-Urbancová, Zdeňka Vitásková, Viktorie Vlachová,
Michaela Kress, and Peter W. Reeh. Inflammatory mediators at acidic pH activate capsaicin …

The role of calcium in capsaicin-induced desensitization in rat cultured dorsal root ganglion neurons

A Cholewinski, GM Burgess, S Bevan - Neuroscience, 1993 - Elsevier
The effects of capsaicin cytosolic Ca 2+ concentration ([Ca 2+] i) were measured in
individual dorsal root ganglion neurons of the rat in culture. Capsaicin produced a rapid …

Fractional Ca2+ Currents through Capsaicin‐ and Proton‐Activated Ion Channels in Rat Dorsal Root Ganglion Neurones

HU Zeilhofer, M Kress… - The Journal of physiology, 1997 - Wiley Online Library
1 Capsaicin and protons cause excitation and sensitization of primary nociceptive afferents.
In a subset of dorsal root ganglion (DRG) neurones, which probably represent nociceptive …

Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture

JN Wood, J Winter, IF James, HP Rang… - Journal of …, 1988 - Soc Neuroscience
Capsaicin is a pungent pain-producing compound found in plants of the capsicum family; it
exerts excitatory, desensitizing, and toxic effects on a subset of sensory neurons, including …

Capsaicin differentially modulates voltage-activated calcium channel currents in dorsal root ganglion neurones of rats

T Hagenacker, F Splettstoesser, W Greffrath… - Brain research, 2005 - Elsevier
It is discussed whether capsaicin, an agonist of the pain mediating TRPV1 receptor,
decreases or increases voltage-activated calcium channel (VACC) currents (ICa (V)). ICa (V) …