Capsaicin ion channels are highly expressed in peripheral nervous terminals and involved
in pain and thermal sensations. One characteristic of the cloned VR1 receptor is its …

Recently, with use of rat dorsal root ganglion (DRG) neurons we have been able to
dissociate the binding affinities of vanilloids from their potencies to induce 45Ca uptake …

Calcium influx through voltage-activated Ca 2+ channels (VACCs) plays a critical role in
neurotransmission. Capsaicin application inhibits VACCs and desensitizes nociceptors. In …

Nicotine and capsaicin produce many similar physiological responses that include pain,
irritation, and vasodilation. To determine whether neuronal nicotine acetylcholine receptors …

In the guinea pig ureter, substance P-(SP) and calcitonin gene-related peptide-(CGRP) like
immunoreactivity (LI) were depleted by systemic capsaicin pretreatment, indicating that they …

Activation of unmyelinated (C-fiber) nociceptors by noxious chemicals plays a critical role in
the initiation and maintenance of injury-induced pain. C-fiber nociceptors can be divided into …

Low pH is a well known sensory irritant in pathological conditions such as inflammation. The
mechanisms underlying this low pH effect were therefore studied in the guinea pig. Acid …

The H+‐gated acid‐sensing ion channels (ASICs) are expressed in dorsal root ganglion
(DRG) neurones. Studies with ASIC knockout mice indicated either a pro‐nociceptive or a …

1. The responses of adult and neonatal rat dorsal root ganglion (DRG) neurones to buffered
acidic solutions were studied with both voltage clamp and radioactive ion flux techniques …

Abstract Development of the pharmacology of Acid-Sensing Ion Channels (ASICs) has
become a key challenge to study their structure, their molecular and cellular functions and …