The acid-sensing ion channels (ASICs) form cation channels that are transiently activated by
extracellular protons. They are expressed in dorsal root ganglia (DRG) neurons and in the …

Recent work on the excitatory action of capsaicin on somatic and visceral afferent neurones
shows that depolarization is selective for C-fibre polymodal nociceptor afferents and …

In the late fifties and sixties Jancso published a series of papers on 'the peculiar
pharmacological effect of capsaicin Capsaicin or 8-methyl-N-vanillyi-6-nonenamide is the …

1. The responses of adult and neonatal rat dorsal root ganglion (DRG) neurones to buffered
acidic solutions were studied with both voltage clamp and radioactive ion flux techniques …

Capsaicin, a pungent ingredient of hot chilli peppers, triggered Ca2+ influx in dorsal root
ganglion (DRG) neurons, which express specific vanilloid receptors of type 1, with ED50< …

Acid sensing is associated with nociception, taste transduction, and perception of
extracellular pH fluctuations in the brain. Acid sensing is carried out by the simplest class of …

Vanilloid receptors are activated by capsaicin, the pungent ingredient in hot pepper. They
are also specifically and competitively inhibited by capsazepine (CPZ). To determine …

Neonatal capsaicin treatment has been shown to cause selective degeneration of
chemosensitive primary sensory neurons involved in the mediation of chemogenic pain and …

Voltage-gated sodium channels (VGSC) are the primary mediators of electrical signal
amplification and propagation in excitable cells. VGSC subtypes are diverse, with different …

Calcium influx through voltage-activated Ca 2+ channels (VACCs) plays a critical role in
neurotransmission. Capsaicin application inhibits VACCs and desensitizes nociceptors. In …