Introduction: Current FDA-approved smoking cessation pharmacotherapies have limited
efficacy and are associated with high rates of relapse. Therefore, there is a clear need to …

Nicotine withdrawal is associated with deficits in neurocognitive function including sustained
attention, working memory, and response inhibition. Several convergent lines of evidence …

Rationale Smoking withdrawal has been widely established to produce a range of
impairments to the quality of several major domains of cognitive function including attention …

This article selectively reviews research concerning nicotine's effects on cognition, including
the neurobiological mechanism for these effects, task and experimental features that may be …

Background: Cigarette smoking is the main cause of preventable death in developed
countries. While the direct positive behavioral reinforcing effect of nicotine has historically …

The therapeutic potential of nicotine for the treatment of disease has been explored at least
since 1926, when Henry Moll experimented with using nicotine to treat the symptoms of …

Smokers have substantial individual differences in quit success in response to current
treatments for nicotine dependence. This observation may suggest that different underlying …

Cigarette smoking rates in the American population are approximately 23%, whereas rates
of smoking in clinical and population studies of individuals with neuropsychiatric disorders …

Nicotine dependence is a chronic, relapsing disorder with complex biological mechanisms
underlying the motivational basis for this behavior. Although more than 70% of current …

Objective: Controversy exists over the effect of tobacco deprivation in nicotine-dependent
individuals and the efficacy of nicotine in reversing performance decrements. This study's …