In this study, we examined whether experimental alterations of circulating estrogen levels
are associated with changes in the expression of bcl-x, an inhibitor of apoptosis. We report …

BCL-2, a protein which negatively modulates apoptosis, is up-regulated by estrogen in
several tissues. To determine the effect of estradiol on Bcl-2 in the adult brain, its …

Recent findings indicate that estrogen is neuroprotective, a cellular effect that may contribute
to its clinical benefits in delaying the development of Alzheimer's disease. In this report, we …

The survival factor Bcl‐2 is a cyclic AMP response element‐binding protein (CREB) gene
product implicated in mediating some of estrogen's effects on neuroprotection. Previously …

Recently we reported that chronic treatment with 17β-estradiol (E2) or tamoxifen (TAM)
regulates the ovariectomy-induced downregulation of the key molecules linked to …

AIMS: The aim of the present study was to investigate the effects of different periods of
ovariectomy and 17β-estradiol replacement on apoptotic cell death and expression of …

We have shown that physiological levels of estradiol exert profound protective effects on the
cerebral cortex in ischemia induced by permanent middle cerebral artery occlusion. The …

Female rodents producing endogenous estrogens are protected from stroke damage in
comparison with male counterparts. This natural protection is lost after ovariectomy or …

EUROPROTECTIVE effects of estrogen have been demonstrated against a variety of
cytotoxic insults. We present data here addressing a possible mechanism of estrogen …

Many clinical studies suggest that estrogen enhances memory and cognition and protects
against neurodegenerative diseases and injury associated with stroke or stress. These …