The nuclear transactive response (TAR) DNA binding protein-43, TDP-43, is a major
constituent of the ubiquitinated neuronal inclusions in patients with frontotemporal lobar …

It has been only 5 years since the identification of TDP-43 as the major protein component of
the ubiquitinated inclusions in FTLD-U. At that time, there were approximately a dozen …

The recent discovery of pathological TDP-43 in both amyotrophic lateral sclerosis and
frontotemporal lobar degeneration with ubiquitinated inclusions confirms that these are …

The pathologic phosphorylation and sub-cellular translocation of neuronal transactive
response-DNA binding protein (TDP-43) was identified as the major disease protein in …

Until 2006, the term “frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-
U)” referred to a classification system with subtypes based on the distribution of neuronal …

Post-encephalitic parkinsonism (PEP) is a neurodegenerative disorder historically known as
the most common sequel of encephalitis lethargica (EL) during the world pandemic between …

Tar-DNA binding protein of 43 kDa (TDP-43) has been characterized as a major component
of protein aggregates in brains with neurodegenerative diseases such as frontotemporal …

Abstract TAR DNA binding protein 43 (TDP-43) pathology is a defining feature of
frontotemporal lobar degeneration (FTLD). In FTLD-TDP there is a moderate-to-high burden …

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are
characterized by cytoplasmic protein aggregates in the brain and spinal cord that include …

Abstract TAR DNA-binding protein 43 (TDP-43) is one of the neuropathological hallmarks in
amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). It is …