Administration of β-lactam antibiotics by extended infusion optimizes the pharmacodynamic
properties and bactericidal activity of these agents resulting in a potential improvement in …

Introduction To enhance the probability of pharmacodynamic target attainment, piperacillin–
tazobactam can be administered as either a continuous or extended-infusion dosage …

Objective The purpose of this study is to evaluate the outcome differences between patients
receiving piperacillin-tazobactam pre-and post-implementation of an extended infusion …

Study Objective. To compare the effectiveness of extended‐infusion piperacillin‐tazobactam
with that of similar‐spectrum, nonextended‐infusion β‐lactam antibiotics in the treatment of …

Purpose The pharmacodynamics and therapeutic effects of extended-infusion (EI)
piperacillin–tazobactam therapy are reviewed, with an emphasis on growing evidence of its …

Background For beta-lactams, the parameter that best predicts bacterial killing is the length
of time the antibiotic concentration exceeds the minimum inhibitory concentration (MIC) …

Purpose The development and implementation of an extended-infusion piperacillin–
tazobactam program at an urban teaching hospital are described. Summary A …

Background: Current medical center practice allows for the automatic conversion of all
piperacillin/tazobactam orders from intermittent to extended infusion (EI). Objective: To …

Objective: To perform a qualitative systematic review of the evidence comparing traditional
strategies against prolonged intermittent or continuous infusion strategies for piperacillin …

Studies evaluating the outcomes of an extended-infusion (EI) piperacillin-tazobactam dosing
strategy in specific cohorts of critically ill patients are lacking. A retrospective, pre …