Many long noncoding RNAs (lncRNAs) are enriched in pancreatic islets and several
lncRNAs are linked to type 2 diabetes (T2D). Although they have emerged as potential …

The advent of insulin treatment in 1923 meant fewer diabetes deaths from acute metabolic
deterioration and sepsis and a progressive increase in the burden of disease caused by end …

Type 2 diabetes mellitus (T2DM) is one of the major chronic diseases, whose prevalence is
increasing dramatically worldwide and can lead to a range of serious complications. Wnt …

Metabolic syndrome is a condition characterized by metabolic alterations that culminate in
chronic noncommunicable diseases of high morbidity and mortality, such as cardiovascular …

miRNA is a short non-coding RNA that can influence mRNA processing at the post-
transcriptional level. A large number of miRNAs have been found in virtually all species so …

MicroRNAs (miRNAs) are small 19–23 nucleo-tide RNA molecules that act as regulators of
protein expression in eukaryotic cells by inducing the translational arrest and degradation of …

Health promotion and prevention of disease has now become of major interest to the
scientific and medical community with genomic medicine now important to modern medicine …

Background Intramyocellular lipid accumulation is strongly related to insulin resistance in
humans, and we have shown that high glucose concentration induced de novo lipogenesis …

Adipose tissue dysfunction plays a pivotal role in the development of insulin resistance in
obese individuals. Cell culture studies and gain-of-function mouse models suggest that …

The capacity of tiny, noncoding RNA molecules (including small, interfering RNA molecules
and micro-RNA molecules [miRNAs]) to control gene expression in a very specific and …